TLK1

Tousled-like kinase 1, also known as TLK1, is a human gene.cite web | title = Entrez Gene: TLK1 tousled-like kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874| accessdate = ]

PBB_Summary
section_title =
summary_text = The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. [supplied by OMIM] cite web | title = Entrez Gene: TLK1 tousled-like kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 |doi=
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Yamakawa A, Kameoka Y, Hashimoto K, "et al." |title=cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. |journal=Gene |volume=202 |issue= 1-2 |pages= 193–201 |year= 1998 |pmid= 9427565 |doi=
*cite journal | author=Silljé HH, Takahashi K, Tanaka K, "et al." |title=Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5691–702 |year= 1999 |pmid= 10523312 |doi= 10.1093/emboj/18.20.5691
*cite journal | author=Cabaniols JP, Ravichandran V, Roche PA |title=Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. |journal=Mol. Biol. Cell |volume=10 |issue= 12 |pages= 4033–41 |year= 2000 |pmid= 10588641 |doi=
*cite journal | author=Li Y, DeFatta R, Anthony C, "et al." |title=A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed. |journal=Oncogene |volume=20 |issue= 6 |pages= 726–38 |year= 2001 |pmid= 11314006 |doi= 10.1038/sj.onc.1204147
*cite journal | author=Silljé HH, Nigg EA |title=Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. |journal=Curr. Biol. |volume=11 |issue= 13 |pages= 1068–73 |year= 2001 |pmid= 11470414 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Groth A, Lukas J, Nigg EA, "et al." |title=Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. |journal=EMBO J. |volume=22 |issue= 7 |pages= 1676–87 |year= 2003 |pmid= 12660173 |doi= 10.1093/emboj/cdg151
*cite journal | author=Krause DR, Jonnalagadda JC, Gatei MH, "et al." |title=Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. |journal=Oncogene |volume=22 |issue= 38 |pages= 5927–37 |year= 2003 |pmid= 12955071 |doi= 10.1038/sj.onc.1206691
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Norton KS, McClusky D, Sen S, "et al." |title=TLK1B is elevated with eIF4E overexpression in breast cancer. |journal=J. Surg. Res. |volume=116 |issue= 1 |pages= 98–103 |year= 2004 |pmid= 14732354 |doi=
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kodym R, Henöckl C, Fürweger C |title=Identification of the human DEAD-box protein p68 as a substrate of Tlk1. |journal=Biochem. Biophys. Res. Commun. |volume=333 |issue= 2 |pages= 411–7 |year= 2005 |pmid= 15950181 |doi= 10.1016/j.bbrc.2005.05.136
*cite journal | author=Sunavala-Dossabhoy G, Balakrishnan SK, Sen S, "et al." |title=The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks. |journal=BMC Mol. Biol. |volume=6 |issue= |pages= 19 |year= 2006 |pmid= 16156902 |doi= 10.1186/1471-2199-6-19
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Sen SP, De Benedetti A |title=TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1. |journal=BMC Mol. Biol. |volume=7 |issue= |pages= 37 |year= 2006 |pmid= 17054786 |doi= 10.1186/1471-2199-7-37

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