Wolf-Hirschhorn syndrome candidate 2, also known as WHSC2, is a human gene.cite web | title = Entrez Gene: WHSC2 Wolf-Hirschhorn syndrome candidate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7469| accessdate = ]

section_title =
summary_text = This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.cite web | title = Entrez Gene: WHSC2 Wolf-Hirschhorn syndrome candidate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7469| accessdate = ] WHSC2 encodes the NELF-A subunit of the NELF complex.cite journal | author = Narita, Takashi | coauthors = Yamaguchi, Yuki ; Yano, Keiichi; Sugimoto, Seiji; Chanarat, Sittinan; Wada, Tadashi; Kim, Dong-ki; Hasegawa, Jun; Omori, Masashi; Inukai, Naoto; Endoh, Masaki; Yamada, Tomoko; Handa, Hiroshi | title = Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex | journal = MOLECULAR AND CELLULAR BIOLOGY | volume = 23 | pages =1863–1873 | year = 2003 | pmid= 12612062 |doi = 10.1128/MCB.23.6.1863-1873.2003]


Further reading

citations =
*cite journal | author=Gutmajster E, Rokicka A |title= [Genetic determination of Wolf-Hirschhorn syndrome ] |journal=Wiad. Lek. |volume=55 |issue= 11-12 |pages= 706–10 |year= 2003 |pmid= 12715353 |doi=
*cite journal | author=Stevens M, De Clercq E, Balzarini J |title=The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. |journal=Med Res Rev |volume=26 |issue= 5 |pages= 595–625 |year= 2007 |pmid= 16838299 |doi= 10.1002/med.20081
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Wright TJ, Ricke DO, Denison K, "et al." |title=A transcript map of the newly defined 165 kb Wolf-Hirschhorn syndrome critical region. |journal=Hum. Mol. Genet. |volume=6 |issue= 2 |pages= 317–24 |year= 1997 |pmid= 9063753 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Yamaguchi Y, Takagi T, Wada T, "et al." |title=NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. |journal=Cell |volume=97 |issue= 1 |pages= 41–51 |year= 1999 |pmid= 10199401 |doi=
*cite journal | author=Wright TJ, Costa JL, Naranjo C, "et al." |title=Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region. |journal=Genomics |volume=59 |issue= 2 |pages= 203–12 |year= 1999 |pmid= 10409432 |doi= 10.1006/geno.1999.5871
*cite journal | author=Ping YH, Rana TM |title=DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12951–8 |year= 2001 |pmid= 11112772 |doi= 10.1074/jbc.M006130200
*cite journal | author=Mariotti M, Manganini M, Maier JA |title=Modulation of WHSC2 expression in human endothelial cells. |journal=FEBS Lett. |volume=487 |issue= 2 |pages= 166–70 |year= 2001 |pmid= 11150502 |doi=
*cite journal | author=Ito M, Shichijo S, Tsuda N, "et al." |title=Molecular basis of T cell-mediated recognition of pancreatic cancer cells. |journal=Cancer Res. |volume=61 |issue= 5 |pages= 2038–46 |year= 2001 |pmid= 11280764 |doi=
*cite journal | author=Yamaguchi Y, Filipovska J, Yano K, "et al." |title=Stimulation of RNA polymerase II elongation by hepatitis delta antigen. |journal=Science |volume=293 |issue= 5527 |pages= 124–7 |year= 2001 |pmid= 11387440 |doi= 10.1126/science.1057925
*cite journal | author=Yamaguchi Y, Inukai N, Narita T, "et al." |title=Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 2918–27 |year= 2002 |pmid= 11940650 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zollino M, Lecce R, Fischetto R, "et al." |title=Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2. |journal=Am. J. Hum. Genet. |volume=72 |issue= 3 |pages= 590–7 |year= 2003 |pmid= 12563561 |doi=
*cite journal | author=Narita T, Yamaguchi Y, Yano K, "et al." |title=Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 1863–73 |year= 2003 |pmid= 12612062 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101

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