CBR1

Carbonyl reductase 1, also known as CBR1, is a human gene.cite web | title = Entrez Gene: CBR1 carbonyl reductase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=873| accessdate = ]

PBB_Summary
section_title =
summary_text = Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.cite web | title = Entrez Gene: CBR1 carbonyl reductase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=873| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wirth H, Wermuth B |title=Immunohistochemical localization of carbonyl reductase in human tissues. |journal=J. Histochem. Cytochem. |volume=40 |issue= 12 |pages= 1857–63 |year= 1992 |pmid= 1453004 |doi=
*cite journal | author=Inazu N, Ruepp B, Wirth H, Wermuth B |title=Carbonyl reductase from human testis: purification and comparison with carbonyl reductase from human brain and rat testis. |journal=Biochim. Biophys. Acta |volume=1116 |issue= 1 |pages= 50–6 |year= 1992 |pmid= 1540623 |doi=
*cite journal | author=Forrest GL, Akman S, Doroshow J, "et al." |title=Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity. |journal=Mol. Pharmacol. |volume=40 |issue= 4 |pages= 502–7 |year= 1991 |pmid= 1921984 |doi=
*cite journal | author=Forrest GL, Akman S, Krutzik S, "et al." |title=Induction of a human carbonyl reductase gene located on chromosome 21. |journal=Biochim. Biophys. Acta |volume=1048 |issue= 2-3 |pages= 149–55 |year= 1990 |pmid= 2182121 |doi=
*cite journal | author=Wermuth B, Platts KL, Seidel A, Oesch F |title=Carbonyl reductase provides the enzymatic basis of quinone detoxication in man. |journal=Biochem. Pharmacol. |volume=35 |issue= 8 |pages= 1277–82 |year= 1986 |pmid= 3083821 |doi=
*cite journal | author=Wermuth B, Bohren KM, Heinemann G, "et al." |title=Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. |journal=J. Biol. Chem. |volume=263 |issue= 31 |pages= 16185–8 |year= 1988 |pmid= 3141401 |doi=
*cite journal | author=Bohren KM, von Wartburg JP, Wermuth B |title=Kinetics of carbonyl reductase from human brain. |journal=Biochem. J. |volume=244 |issue= 1 |pages= 165–71 |year= 1987 |pmid= 3311025 |doi=
*cite journal | author=Wermuth B |title=Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. |journal=J. Biol. Chem. |volume=256 |issue= 3 |pages= 1206–13 |year= 1981 |pmid= 7005231 |doi=
*cite journal | author=Wermuth B, Mäder-Heinemann G, Ernst E |title=Cloning and expression of carbonyl reductase from rat testis. |journal=Eur. J. Biochem. |volume=228 |issue= 2 |pages= 473–9 |year= 1995 |pmid= 7705364 |doi=
*cite journal | author=Krook M, Ghosh D, Strömberg R, "et al." |title=Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 2 |pages= 502–6 |year= 1993 |pmid= 8421682 |doi=
*cite journal | author=Lemieux N, Malfoy B, Forrest GL |title=Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells. |journal=Genomics |volume=15 |issue= 1 |pages= 169–72 |year= 1993 |pmid= 8432528 |doi= 10.1006/geno.1993.1024
*cite journal | author=Watanabe K, Sugawara C, Ono A, "et al." |title=Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. |journal=Genomics |volume=52 |issue= 1 |pages= 95–100 |year= 1999 |pmid= 9740676 |doi= 10.1006/geno.1998.5380
*cite journal | author=Tinguely JN, Wermuth B |title=Identification of the reactive cysteine residue (Cys227) in human carbonyl reductase. |journal=Eur. J. Biochem. |volume=260 |issue= 1 |pages= 9–14 |year= 1999 |pmid= 10091578 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Finckh C, Atalla A, Nagel G, "et al." |title=Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung. |journal=Chem. Biol. Interact. |volume=130-132 |issue= 1-3 |pages= 761–73 |year= 2001 |pmid= 11306092 |doi=
*cite journal | author=Balcz B, Kirchner L, Cairns N, "et al." |title=Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 193–201 |year= 2002 |pmid= 11771743 |doi=
*cite journal | author=Skálová L, Nobilis M, Szotáková B, "et al." |title=Carbonyl reduction of the potential cytostatic drugs benfluron and 3,9-dimethoxybenfluron in human in vitro. |journal=Biochem. Pharmacol. |volume=64 |issue= 2 |pages= 297–305 |year= 2002 |pmid= 12123751 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cheon MS, Shim KS, Kim SH, "et al." |title=Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV). |journal=Amino Acids |volume=25 |issue= 1 |pages= 41–7 |year= 2004 |pmid= 12836057 |doi= 10.1007/s00726-003-0009-9
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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