RTN1

Reticulon 1, also known as RTN1, is a human gene.cite web | title = Entrez Gene: RTN1 reticulon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6252| accessdate = ]

PBB_Summary
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summary_text = This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.cite web | title = Entrez Gene: RTN1 reticulon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6252| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Senden NH, van de Velde HJ, Broers JL, "et al." |title=Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum. |journal=Int. J. Cancer Suppl. |volume=8 |issue= |pages= 84–8 |year= 1994 |pmid= 7515034 |doi=
*cite journal | author=Roebroek AJ, van de Velde HJ, Van Bokhoven A, "et al." |title=Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product. |journal=J. Biol. Chem. |volume=268 |issue= 18 |pages= 13439–47 |year= 1993 |pmid= 7685762 |doi=
*cite journal | author=van de Velde HJ, Roebroek AJ, Senden NH, "et al." |title=NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum. |journal=J. Cell. Sci. |volume=107 ( Pt 9) |issue= |pages= 2403–16 |year= 1995 |pmid= 7844160 |doi=
*cite journal | author=van de Velde HJ, Senden NH, Roskams TA, "et al." |title=NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. |journal=Cancer Res. |volume=54 |issue= 17 |pages= 4769–76 |year= 1994 |pmid= 8062278 |doi=
*cite journal | author=Kools PF, Roebroek AJ, Van de Velde HJ, "et al." |title=Regional mapping of the human NSP gene to chromosome region 14q21-->q22 by fluorescence in situ hybridization analysis. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 1 |pages= 48–50 |year= 1994 |pmid= 8275708 |doi=
*cite journal | author=Roebroek AJ, Ayoubi TA, Van de Velde HJ, "et al." |title=Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons. |journal=Genomics |volume=32 |issue= 2 |pages= 191–9 |year= 1997 |pmid= 8833145 |doi= 10.1006/geno.1996.0105
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Senden NH, Timmer ED, Boers JE, "et al." |title=Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A. |journal=Eur. J. Cell Biol. |volume=69 |issue= 3 |pages= 197–213 |year= 1996 |pmid= 8900485 |doi=
*cite journal | author=Hens J, Nuydens R, Geerts H, "et al." |title=Neuronal differentiation is accompanied by NSP-C expression. |journal=Cell Tissue Res. |volume=292 |issue= 2 |pages= 229–37 |year= 1998 |pmid= 9560466 |doi=
*cite journal | author=Tagami S, Eguchi Y, Kinoshita M, "et al." |title=A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. |journal=Oncogene |volume=19 |issue= 50 |pages= 5736–46 |year= 2001 |pmid= 11126360 |doi= 10.1038/sj.onc.1203948
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Oertle T, Klinger M, Stuermer CA, Schwab ME |title=A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. |journal=FASEB J. |volume=17 |issue= 10 |pages= 1238–47 |year= 2003 |pmid= 12832288 |doi= 10.1096/fj.02-1166hyp
*cite journal | author=Di Sano F, Fazi B, Citro G, "et al." |title=Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. |journal=Cancer Res. |volume=63 |issue= 14 |pages= 3860–5 |year= 2003 |pmid= 12873973 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Iwahashi J, Hamada N |title=Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=49 Online Pub |issue= |pages= OL467–71 |year= 2004 |pmid= 14995077 |doi=
*cite journal | author=Hu Y, Fang X, Dunham SM, "et al." |title=90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29325–35 |year= 2004 |pmid= 15117958 |doi= 10.1074/jbc.M311144200
*cite journal | author=He W, Lu Y, Qahwash I, "et al." |title=Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. |journal=Nat. Med. |volume=10 |issue= 9 |pages= 959–65 |year= 2004 |pmid= 15286784 |doi= 10.1038/nm1088
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Mannan AU, Boehm J, Sauter SM, "et al." |title=Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein. |journal=Neurogenetics |volume=7 |issue= 2 |pages= 93–103 |year= 2007 |pmid= 16602018 |doi= 10.1007/s10048-006-0034-4

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