ROBO1

ROBO1

Roundabout, axon guidance receptor, homolog 1 (Drosophila), also known as ROBO1, is a human gene.cite web | title = Entrez Gene: ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6091| accessdate = ]

PBB_Summary
section_title =
summary_text = Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. In Drosophila, the roundabout gene, a member of the immunoglobulin gene superfamily, encodes an integral membrane protein that is both an axon guidance receptor and a cell adhesion receptor. This receptor is involved in the decision by axons to cross the central nervous system midline. The protein encoded by this gene is structurally similar to the Drosophila roundabout protein. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6091| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kidd T, Brose K, Mitchell KJ, "et al." |title=Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. |journal=Cell |volume=92 |issue= 2 |pages= 205–15 |year= 1998 |pmid= 9458045 |doi=
*cite journal | author=Sundaresan V, Roberts I, Bateman A, "et al." |title=The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 1-2 |pages= 29–35 |year= 1998 |pmid= 9608531 |doi= 10.1006/mcne.1998.0672
*cite journal | author=Sundaresan V, Chung G, Heppell-Parton A, "et al." |title=Homozygous deletions at 3p12 in breast and lung cancer. |journal=Oncogene |volume=17 |issue= 13 |pages= 1723–9 |year= 1998 |pmid= 9796701 |doi= 10.1038/sj.onc.1202103
*cite journal | author=Brose K, Bland KS, Wang KH, "et al." |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. |journal=Cell |volume=96 |issue= 6 |pages= 795–806 |year= 1999 |pmid= 10102268 |doi=
*cite journal | author=Yuan W, Zhou L, Chen JH, "et al." |title=The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. |journal=Dev. Biol. |volume=212 |issue= 2 |pages= 290–306 |year= 1999 |pmid= 10433822 |doi= 10.1006/dbio.1999.9371
*cite journal | author=Bashaw GJ, Kidd T, Murray D, "et al." |title=Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. |journal=Cell |volume=101 |issue= 7 |pages= 703–15 |year= 2000 |pmid= 10892742 |doi=
*cite journal | author=Nguyen Ba-Charvet KT, Brose K, Ma L, "et al." |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281–9 |year= 2001 |pmid= 11404413 |doi=
*cite journal | author=Wong K, Ren XR, Huang YZ, "et al." |title=Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. |journal=Cell |volume=107 |issue= 2 |pages= 209–21 |year= 2001 |pmid= 11672528 |doi=
*cite journal | author=Dallol A, Forgacs E, Martinez A, "et al." |title=Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. |journal=Oncogene |volume=21 |issue= 19 |pages= 3020–8 |year= 2002 |pmid= 12082532 |doi= 10.1038/sj.onc.1205421
*cite journal | author=Latil A, Chêne L, Cochant-Priollet B, "et al." |title=Quantification of expression of netrins, slits and their receptors in human prostate tumors. |journal=Int. J. Cancer |volume=103 |issue= 3 |pages= 306–15 |year= 2003 |pmid= 12471613 |doi= 10.1002/ijc.10821
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hivert B, Liu Z, Chuang CY, "et al." |title=Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 534–45 |year= 2003 |pmid= 12504588 |doi=
*cite journal | author=Wang B, Xiao Y, Ding BB, "et al." |title=Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. |journal=Cancer Cell |volume=4 |issue= 1 |pages= 19–29 |year= 2004 |pmid= 12892710 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, "et al." |title=The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. |journal=PLoS Genet. |volume=1 |issue= 4 |pages= e50 |year= 2006 |pmid= 16254601 |doi= 10.1371/journal.pgen.0010050
*cite journal | author=Werbowetski-Ogilvie TE, Seyed Sadr M, Jabado N, "et al." |title=Inhibition of medulloblastoma cell invasion by Slit. |journal=Oncogene |volume=25 |issue= 37 |pages= 5103–12 |year= 2006 |pmid= 16636676 |doi= 10.1038/sj.onc.1209524
*cite journal | author=Muzny DM, Scherer SE, Kaul R, "et al." |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728
*cite journal | author=Gröne J, Doebler O, Loddenkemper C, "et al." |title=Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. |journal=Oncol. Rep. |volume=15 |issue= 6 |pages= 1437–43 |year= 2007 |pmid= 16685377 |doi=
*cite journal | author=Ito H, Funahashi S, Yamauchi N, "et al." |title=Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. |journal=Clin. Cancer Res. |volume=12 |issue= 11 Pt 1 |pages= 3257–64 |year= 2007 |pmid= 16740745 |doi= 10.1158/1078-0432.CCR-05-2787

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