SEPT4

Septin 4, also known as SEPT4, is a human gene.cite web | title = Entrez Gene: SEPT4 septin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5414| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: SEPT4 septin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5414| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Paavola P, Horelli-Kuitunen N, Palotie A, Peltonen L |title=Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. |journal=Genomics |volume=55 |issue= 1 |pages= 122–5 |year= 1999 |pmid= 9889007 |doi= 10.1006/geno.1998.5612
*cite journal | author=Xie H, Surka M, Howard J, Trimble WS |title=Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins. |journal=Cell Motil. Cytoskeleton |volume=43 |issue= 1 |pages= 52–62 |year= 1999 |pmid= 10340703 |doi= 10.1002/(SICI)1097-0169(1999)43:1<52::AID-CM6>3.0.CO;2-5 |doilabel=10.1002/(SICI)1097-0169(1999)43:152::AID-CM63.0.CO;2-5
*cite journal | author=Larisch S, Yi Y, Lotan R, "et al." |title=A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. |journal=Nat. Cell Biol. |volume=2 |issue= 12 |pages= 915–21 |year= 2001 |pmid= 11146656 |doi= 10.1038/35046566
*cite journal | author=Zieger B, Tran H, Hainmann I, "et al." |title=Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. |journal=Gene |volume=261 |issue= 2 |pages= 197–203 |year= 2001 |pmid= 11167005 |doi=
*cite journal | author=Tanaka M, Tanaka T, Kijima H, "et al." |title=Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 3 |pages= 547–53 |year= 2001 |pmid= 11511094 |doi= 10.1006/bbrc.2001.5413
*cite journal | author=Tanaka M, Kijima H, Itoh J, "et al." |title=Impaired expression of a human septin family gene Bradeion inhibits the growth and tumorigenesis of colorectal cancer in vitro and in vivo. |journal=Cancer Gene Ther. |volume=9 |issue= 6 |pages= 483–8 |year= 2002 |pmid= 12032658 |doi= 10.1038/sj.cgt.7700460
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vega IE, Hsu SC |title=The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. |journal=Neuroreport |volume=14 |issue= 1 |pages= 31–7 |year= 2003 |pmid= 12544826 |doi= 10.1097/01.wnr.0000050304.92401.50
*cite journal | author=Ihara M, Tomimoto H, Kitayama H, "et al." |title=Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 24095–102 |year= 2003 |pmid= 12695511 |doi= 10.1074/jbc.M301352200
*cite journal | author=Choi P, Snyder H, Petrucelli L, "et al." |title=SEPT5_v2 is a parkin-binding protein. |journal=Brain Res. Mol. Brain Res. |volume=117 |issue= 2 |pages= 179–89 |year= 2004 |pmid= 14559152 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gottfried Y, Rotem A, Lotan R, "et al." |title=The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. |journal=EMBO J. |volume=23 |issue= 7 |pages= 1627–35 |year= 2005 |pmid= 15029247 |doi= 10.1038/sj.emboj.7600155
*cite journal | author=Bläser S, Horn J, Würmell P, "et al." |title=The novel human platelet septin SEPT8 is an interaction partner of SEPT4. |journal=Thromb. Haemost. |volume=91 |issue= 5 |pages= 959–66 |year= 2004 |pmid= 15116257 |doi= 10.1267/THRO04050959
*cite journal | author=Elhasid R, Sahar D, Merling A, "et al." |title=Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients. |journal=Oncogene |volume=23 |issue= 32 |pages= 5468–75 |year= 2004 |pmid= 15122323 |doi= 10.1038/sj.onc.1207725
*cite journal | author=Martínez C, Sanjuan MA, Dent JA, "et al." |title=Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol. |journal=Biochem. J. |volume=382 |issue= Pt 3 |pages= 783–91 |year= 2005 |pmid= 15214843 |doi= 10.1042/BJ20040372
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lotan R, Rotem A, Gonen H, "et al." |title=Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation. |journal=J. Biol. Chem. |volume=280 |issue= 27 |pages= 25802–10 |year= 2005 |pmid= 15837787 |doi= 10.1074/jbc.M501955200
*cite journal | author=Lee JW, Soung YH, Young Kim S, "et al." |title=Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers. |journal=Pathol. Res. Pract. |volume=202 |issue= 2 |pages= 67–70 |year= 2006 |pmid= 16376484 |doi= 10.1016/j.prp.2005.11.001
*cite journal | author=Lee JW, Soung YH, Kim SY, "et al." |title=Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas. |journal=Acta oncologica (Stockholm, Sweden) |volume=45 |issue= 1 |pages= 101–2 |year= 2006 |pmid= 16464805 |doi= 10.1080/02841860500374497
*cite journal | author=Garcia W, de Araújo AP, Neto Mde O, "et al." |title=Dissection of a human septin: definition and characterization of distinct domains within human SEPT4. |journal=Biochemistry |volume=45 |issue= 46 |pages= 13918–31 |year= 2007 |pmid= 17105210 |doi= 10.1021/bi061549z

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