LIMS1

LIM and senescent cell antigen-like domains 1, also known as LIMS1, is a human gene.cite web | title = Entrez Gene: LIMS1 LIM and senescent cell antigen-like domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3987| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.cite web | title = Entrez Gene: LIMS1 LIM and senescent cell antigen-like domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3987| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rearden A |title=A new LIM protein containing an autoepitope homologous to "senescent cell antigen". |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1124–31 |year= 1994 |pmid= 7517666 |doi= 10.1006/bbrc.1994.1822
*cite journal | author=Tu Y, Li F, Wu C |title=Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. |journal=Mol. Biol. Cell |volume=9 |issue= 12 |pages= 3367–82 |year= 1999 |pmid= 9843575 |doi=
*cite journal | author=Tu Y, Li F, Goicoechea S, Wu C |title=The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2425–34 |year= 1999 |pmid= 10022929 |doi=
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Velyvis A, Yang Y, Wu C, Qin J |title=Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4932–9 |year= 2001 |pmid= 11078733 |doi= 10.1074/jbc.M007632200
*cite journal | author=Tu Y, Huang Y, Zhang Y, "et al." |title=A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 585–98 |year= 2001 |pmid= 11331308 |doi=
*cite journal | author=Zhang Y, Chen K, Tu Y, "et al." |title=Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. |journal=J. Cell. Sci. |volume=115 |issue= Pt 24 |pages= 4777–86 |year= 2003 |pmid= 12432066 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Campana WM, Myers RR, Rearden A |title=Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. |journal=Glia |volume=41 |issue= 3 |pages= 213–23 |year= 2003 |pmid= 12528177 |doi= 10.1002/glia.10138
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Velyvis A, Vaynberg J, Yang Y, "et al." |title=Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. |journal=Nat. Struct. Biol. |volume=10 |issue= 7 |pages= 558–64 |year= 2003 |pmid= 12794636 |doi= 10.1038/nsb938
*cite journal | author=Fukuda T, Chen K, Shi X, Wu C |title=PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51324–33 |year= 2004 |pmid= 14551191 |doi= 10.1074/jbc.M309122200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bock-Marquette I, Saxena A, White MD, "et al." |title=Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. |journal=Nature |volume=432 |issue= 7016 |pages= 466–72 |year= 2004 |pmid= 15565145 |doi= 10.1038/nature03000
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Dougherty GW, Chopp T, Qi SM, Cutler ML |title=The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions. |journal=Exp. Cell Res. |volume=306 |issue= 1 |pages= 168–79 |year= 2005 |pmid= 15878342 |doi= 10.1016/j.yexcr.2005.01.025
*cite journal | author=Xu Z, Fukuda T, Li Y, "et al." |title=Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27631–7 |year= 2005 |pmid= 15941716 |doi= 10.1074/jbc.M504189200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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