LGALS8

Lectin, galactoside-binding, soluble, 8 (galectin 8), also known as LGALS8, is a human gene.cite web | title = Entrez Gene: LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3964| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3964| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bidon N, Brichory F, Bourguet P, "et al." |title=Galectin-8: a complex sub-family of galectins (Review). |journal=Int. J. Mol. Med. |volume=8 |issue= 3 |pages= 245–50 |year= 2001 |pmid= 11494049 |doi=
*cite journal | author=Danguy A, Camby I, Kiss R |title=Galectins and cancer. |journal=Biochim. Biophys. Acta |volume=1572 |issue= 2-3 |pages= 285–93 |year= 2002 |pmid= 12223276 |doi=
*cite journal | author=Bidon-Wagner N, Le Pennec JP |title=Human galectin-8 isoforms and cancer. |journal=Glycoconj. J. |volume=19 |issue= 7-9 |pages= 557–63 |year= 2004 |pmid= 14758080 |doi= 10.1023/B:GLYC.0000014086.38343.98
*cite journal | author=Hadari YR, Paz K, Dekel R, "et al." |title=Galectin-8. A new rat lectin, related to galectin-4. |journal=J. Biol. Chem. |volume=270 |issue= 7 |pages= 3447–53 |year= 1995 |pmid= 7852431 |doi=
*cite journal | author=Su ZZ, Lin J, Shen R, "et al." |title=Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7252–7 |year= 1996 |pmid= 8692978 |doi=
*cite journal | author=Bassen R, Brichory F, Caulet-Maugendre S, "et al." |title=Expression of Po66-CBP, a type-8 galectin, in different healthy, tumoral and peritumoral tissues. |journal=Anticancer Res. |volume=19 |issue= 6B |pages= 5429–33 |year= 2000 |pmid= 10697573 |doi=
*cite journal | author=Hadari YR, Arbel-Goren R, Levy Y, "et al." |title=Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. |journal=J. Cell. Sci. |volume=113 ( Pt 13) |issue= |pages= 2385–97 |year= 2000 |pmid= 10852818 |doi=
*cite journal | author=Gopalkrishnan RV, Roberts T, Tuli S, "et al." |title=Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. |journal=Oncogene |volume=19 |issue= 38 |pages= 4405–16 |year= 2000 |pmid= 10980616 |doi= 10.1038/sj.onc.1203767
*cite journal | author=Bidon N, Brichory F, Hanash S, "et al." |title=Two messenger RNAs and five isoforms for Po66-CBP, a galectin-8 homolog in a human lung carcinoma cell line. |journal=Gene |volume=274 |issue= 1-2 |pages= 253–62 |year= 2001 |pmid= 11675018 |doi=
*cite journal | author=Nagy N, Bronckart Y, Camby I, "et al." |title=Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor. |journal=Gut |volume=50 |issue= 3 |pages= 392–401 |year= 2002 |pmid= 11839721 |doi=
*cite journal | author=Maier C, Rösch K, Herkommer K, "et al." |title=A candidate gene approach within the susceptibility region PCaP on 1q42.2-43 excludes deleterious mutations of the PCTA-1 gene to be responsible for hereditary prostate cancer. |journal=Eur. Urol. |volume=42 |issue= 3 |pages= 301–7 |year= 2003 |pmid= 12234517 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Levy Y, Ronen D, Bershadsky AD, Zick Y |title=Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14533–42 |year= 2003 |pmid= 12569102 |doi= 10.1074/jbc.M207380200
*cite journal | author=Ideo H, Seko A, Ishizuka I, Yamashita K |title=The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity. |journal=Glycobiology |volume=13 |issue= 10 |pages= 713–23 |year= 2004 |pmid= 12851289 |doi= 10.1093/glycob/cwg094
*cite journal | author=Nishi N, Shoji H, Seki M, "et al." |title=Galectin-8 modulates neutrophil function via interaction with integrin alphaM. |journal=Glycobiology |volume=13 |issue= 11 |pages= 755–63 |year= 2004 |pmid= 12881409 |doi= 10.1093/glycob/cwg102
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Arbel-Goren R, Levy Y, Ronen D, Zick Y |title=Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 19105–14 |year= 2005 |pmid= 15753078 |doi= 10.1074/jbc.M502060200

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