FKBP1B

FK506 binding protein 1B, 12.6 kDa, also known as FKBP1B, is a human gene.cite web | title = Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2281| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.cite web | title = Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2281| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schiene-Fischer C, Yu C |title=Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. |journal=FEBS Lett. |volume=495 |issue= 1-2 |pages= 1–6 |year= 2001 |pmid= 11322937 |doi=
*cite journal | author=Arakawa H, Nagase H, Hayashi N, "et al." |title=Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 2 |pages= 836–43 |year= 1994 |pmid= 7513996 |doi=
*cite journal | author=Lam E, Martin MM, Timerman AP, "et al." |title=A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26511–22 |year= 1995 |pmid= 7592869 |doi=
*cite journal | author=Noguchi N, Takasawa S, Nata K, "et al." |title=Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3133–6 |year= 1997 |pmid= 9013543 |doi=
*cite journal | author=Deivanayagam CC, Carson M, Thotakura A, "et al." |title=Structure of FKBP12.6 in complex with rapamycin. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=56 |issue= Pt 3 |pages= 266–71 |year= 2000 |pmid= 10713512 |doi=
*cite journal | author=Marx SO, Reiken S, Hisamatsu Y, "et al." |title=PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. |journal=Cell |volume=101 |issue= 4 |pages= 365–76 |year= 2000 |pmid= 10830164 |doi=
*cite journal | author=Jeyakumar LH, Ballester L, Cheng DS, "et al." |title=FKBP binding characteristics of cardiac microsomes from diverse vertebrates. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 4 |pages= 979–86 |year= 2001 |pmid= 11237759 |doi= 10.1006/bbrc.2001.4444
*cite journal | author=George CH, Sorathia R, Bertrand BM, Lai FA |title=In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. |journal=Biochem. J. |volume=370 |issue= Pt 2 |pages= 579–89 |year= 2003 |pmid= 12443530 |doi= 10.1042/BJ20021433
*cite journal | author=Masumiya H, Wang R, Zhang J, "et al." |title=Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor). |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3786–92 |year= 2003 |pmid= 12446682 |doi= 10.1074/jbc.M210962200
*cite journal | author=Tiso N, Salamon M, Bagattin A, "et al." |title=The binding of the RyR2 calcium channel to its gating protein FKBP12.6 is oppositely affected by ARVD2 and VTSIP mutations. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 594–8 |year= 2003 |pmid= 12459180 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=George CH, Higgs GV, Mackrill JJ, Lai FA |title=Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28856–64 |year= 2003 |pmid= 12754204 |doi= 10.1074/jbc.M212440200
*cite journal | author=Nishanian TG, Waldman T |title=Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 91–7 |year= 2004 |pmid= 15351706 |doi= 10.1016/j.bbrc.2004.08.060
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Maalej A, Mbarki F, Rebai A, "et al." |title=Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family. |journal=Autoimmunity |volume=37 |issue= 3 |pages= 237–9 |year= 2005 |pmid= 15497458 |doi=
*cite journal | author=Zissimopoulos S, Lai FA |title=Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5475–85 |year= 2005 |pmid= 15591045 |doi= 10.1074/jbc.M412954200
*cite journal | author=Aizawa Y, Ueda K, Komura S, "et al." |title=A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia. |journal=Int. J. Cardiol. |volume=99 |issue= 2 |pages= 343–5 |year= 2005 |pmid= 15749201 |doi= 10.1016/j.ijcard.2003.11.050
*cite journal | author=Wehrens XH, Lehnart SE, Reiken S, "et al." |title=Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 27 |pages= 9607–12 |year= 2005 |pmid= 15972811 |doi= 10.1073/pnas.0500353102
*cite journal | author=Won J, Kim M, Yi YW, "et al." |title=A magnetic nanoprobe technology for detecting molecular interactions in live cells. |journal=Science |volume=309 |issue= 5731 |pages= 121–5 |year= 2005 |pmid= 15994554 |doi= 10.1126/science.1112869

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