CRSP3

Cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa, also known as CRSP3, is a human gene.cite web | title = Entrez Gene: CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9439| accessdate = ]

PBB_Summary
section_title =
summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9439| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446–50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141
*cite journal | author=Rachez C, Lemon BD, Suldan Z, "et al." |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783
*cite journal | author=Näär AM, Beaurang PA, Zhou S, "et al." |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789
*cite journal | author=Boyer TG, Martin ME, Lees E, "et al." |title=Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. |journal=Nature |volume=399 |issue= 6733 |pages= 276–9 |year= 1999 |pmid= 10353252 |doi= 10.1038/20466
*cite journal | author=Nagase T, Ishikawa K, Kikuno R, "et al." |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=
*cite journal | author=Ko L, Cardona GR, Chin WW |title=Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 6212–7 |year= 2000 |pmid= 10823961 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Stevens JL, Cantin GT, Wang G, "et al." |title=Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. |journal=Science |volume=296 |issue= 5568 |pages= 755–8 |year= 2002 |pmid= 11934987 |doi= 10.1126/science.1068943
*cite journal | author=Asada S, Choi Y, Yamada M, "et al." |title=External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12747–52 |year= 2002 |pmid= 12242338 |doi= 10.1073/pnas.202162199
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Goldberg SF, Miele ME, Hatta N, "et al." |title=Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. |journal=Cancer Res. |volume=63 |issue= 2 |pages= 432–40 |year= 2003 |pmid= 12543799 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Sato S, Tomomori-Sato C, Banks CA, "et al." |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200
*cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, "et al." |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200
*cite journal | author=Mo X, Kowenz-Leutz E, Xu H, Leutz A |title=Ras induces mediator complex exchange on C/EBP beta. |journal=Mol. Cell |volume=13 |issue= 2 |pages= 241–50 |year= 2004 |pmid= 14759369 |doi=
*cite journal | author=Sato S, Tomomori-Sato C, Parmely TJ, "et al." |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006
*cite journal | author=Wada O, Oishi H, Takada I, "et al." |title=BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220. |journal=Oncogene |volume=23 |issue= 35 |pages= 6000–5 |year= 2004 |pmid= 15208681 |doi= 10.1038/sj.onc.1207786
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704

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