RGS3

Regulator of G-protein signalling 3, also known as RGS3, is a human gene.cite web | title = Entrez Gene: RGS3 regulator of G-protein signalling 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5998| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.cite web | title = Entrez Gene: RGS3 regulator of G-protein signalling 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5998| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Druey KM, Blumer KJ, Kang VH, Kehrl JH |title=Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. |journal=Nature |volume=379 |issue= 6567 |pages= 742–6 |year= 1996 |pmid= 8602223 |doi= 10.1038/379742a0
*cite journal | author=Chatterjee TK, Eapen A, Kanis AB, Fisher RA |title=Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene. |journal=Genomics |volume=45 |issue= 2 |pages= 429–33 |year= 1998 |pmid= 9344672 |doi= 10.1006/geno.1997.4929
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Dulin NO, Sorokin A, Reed E, "et al." |title=RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 714–23 |year= 1999 |pmid= 9858594 |doi=
*cite journal | author=Dulin NO, Pratt P, Tiruppathi C, "et al." |title=Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21317–23 |year= 2000 |pmid= 10749886 |doi= 10.1074/jbc.M910079199
*cite journal | author=Linares JL, Wendling C, Tomasetto C, Rio MC |title=C2PA, a new protein expressed during mouse spermatogenesis. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 249–54 |year= 2000 |pmid= 11034339 |doi=
*cite journal | author=Shi CS, Lee SB, Sinnarajah S, "et al." |title=Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24293–300 |year= 2001 |pmid= 11294858 |doi= 10.1074/jbc.M100089200
*cite journal | author=Lu Q, Sun EE, Klein RS, Flanagan JG |title=Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. |journal=Cell |volume=105 |issue= 1 |pages= 69–79 |year= 2001 |pmid= 11301003 |doi=
*cite journal | author=Mittmann C, Schüler C, Chung CH, "et al." |title=Evidence for a short form of RGS3 preferentially expressed in the human heart. |journal=Naunyn Schmiedebergs Arch. Pharmacol. |volume=363 |issue= 4 |pages= 456–63 |year= 2001 |pmid= 11330340 |doi=
*cite journal | author=Niu J, Scheschonka A, Druey KM, "et al." |title=RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 677–84 |year= 2002 |pmid= 11985497 |doi= 10.1042/BJ20020390
*cite journal | author=Kehrl JH, Srikumar D, Harrison K, "et al." |title=Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3. |journal=Genomics |volume=79 |issue= 6 |pages= 860–8 |year= 2002 |pmid= 12036301 |doi= 10.1006/geno.2002.6773
*cite journal | author=Ikeda M, Okai M, Miyoshi T, "et al." |title=Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha. |journal=Horm. Metab. Res. |volume=34 |issue= 8 |pages= 425–30 |year= 2003 |pmid= 12198596 |doi= 10.1055/s-2002-33599
*cite journal | author=Hirabayashi S, Ohno H, Iida J, Hata Y |title=C2PA is a nuclear protein implicated in the heat shock response. |journal=J. Cell. Biochem. |volume=87 |issue= 1 |pages= 65–74 |year= 2003 |pmid= 12210723 |doi= 10.1002/jcb.10279
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Tovey SC, Willars GB |title=Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor. |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1453–64 |year= 2005 |pmid= 15383626 |doi= 10.1124/mol.104.005827
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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