PPP2R2C

Protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform, also known as PPP2R2C, is a human gene.cite web | title = Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5522| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5522| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=
*cite journal | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=
*cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11
*cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279
*cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=
*cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, "et al." |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=
*cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873
*cite journal | author=Strack S, Zaucha JA, Ebner FF, "et al." |title=Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. |journal=J. Comp. Neurol. |volume=392 |issue= 4 |pages= 515–27 |year= 1998 |pmid= 9514514 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Torres R, Ide SE, Dehejia A, "et al." |title=Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit. |journal=DNA Res. |volume=6 |issue= 5 |pages= 323–7 |year= 2000 |pmid= 10574460 |doi=
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956
*cite journal | author=Hu P, Yu L, Zhang M, "et al." |title=Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16. |journal=Genomics |volume=67 |issue= 1 |pages= 83–6 |year= 2001 |pmid= 10945473 |doi= 10.1006/geno.2000.6219
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3918 |year= 2002 |pmid= 12110603 |doi= 10.1093/emboj/cdf420
*cite journal | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, "et al." |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163–70 |year= 2002 |pmid= 12136098 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shern JF, Sharer JD, Pallas DC, "et al." |title=Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 40829–36 |year= 2003 |pmid= 12912990 |doi= 10.1074/jbc.M308678200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Chen W, Possemato R, Campbell KT, "et al." |title=Identification of specific PP2A complexes involved in human cell transformation. |journal=Cancer Cell |volume=5 |issue= 2 |pages= 127–36 |year= 2004 |pmid= 14998489 |doi=

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