GABRB1

Gamma-aminobutyric acid (GABA) A receptor, beta 1, also known as GABRB1, is a human gene.cite web | title = Entrez Gene: GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2560| accessdate = ]

PBB_Summary
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summary_text = The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.cite web | title = Entrez Gene: GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2560| accessdate = ]

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Moss SJ, Doherty CA, Huganir RL |title=Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor. |journal=J. Biol. Chem. |volume=267 |issue= 20 |pages= 14470–6 |year= 1992 |pmid= 1321150 |doi=
*cite journal | author=Moss SJ, Smart TG, Blackstone CD, Huganir RL |title=Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation. |journal=Science |volume=257 |issue= 5070 |pages= 661–5 |year= 1992 |pmid= 1323140 |doi=
*cite journal | author=Dean M, Lucas-Derse S, Bolos A, "et al." |title=Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism. |journal=Am. J. Hum. Genet. |volume=49 |issue= 3 |pages= 621–6 |year= 1991 |pmid= 1652891 |doi=
*cite journal | author=Kirkness EF, Kusiak JW, Fleming JT, "et al." |title=Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1). |journal=Genomics |volume=10 |issue= 4 |pages= 985–95 |year= 1991 |pmid= 1655634 |doi=
*cite journal | author=Garrett KM, Saito N, Duman RS, "et al." |title=Differential expression of gamma-aminobutyric acidA receptor subunits. |journal=Mol. Pharmacol. |volume=37 |issue= 5 |pages= 652–7 |year= 1990 |pmid= 2160058 |doi=
*cite journal | author=Schofield PR, Pritchett DB, Sontheimer H, "et al." |title=Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. |journal=FEBS Lett. |volume=244 |issue= 2 |pages= 361–4 |year= 1989 |pmid= 2465923 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Coon H, Sobell J, Heston L, "et al." |title=Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia. |journal=Am. J. Med. Genet. |volume=54 |issue= 1 |pages= 12–20 |year= 1994 |pmid= 8178835 |doi= 10.1002/ajmg.1320540105
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Russek SJ |title=Evolution of GABA(A) receptor diversity in the human genome. |journal=Gene |volume=227 |issue= 2 |pages= 213–22 |year= 1999 |pmid= 10023064 |doi=
*cite journal | author=McDonald BJ, Amato A, Connolly CN, "et al." |title=Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase. |journal=Nat. Neurosci. |volume=1 |issue= 1 |pages= 23–8 |year= 1999 |pmid= 10195104 |doi= 10.1038/223
*cite journal | author=Bonnert TP, McKernan RM, Farrar S, "et al." |title=theta, a novel gamma-aminobutyric acid type A receptor subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9891–6 |year= 1999 |pmid= 10449790 |doi=
*cite journal | author=Russek SJ, Bandyopadhyay S, Farb DH |title=An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8600–5 |year= 2000 |pmid= 10900018 |doi=
*cite journal | author=Buckley ST, Eckert AL, Dodd PR |title=Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex. |journal=Ann. N. Y. Acad. Sci. |volume=914 |issue= |pages= 58–64 |year= 2006 |pmid= 11085308 |doi=
*cite journal | author=Schaerer MT, Kannenberg K, Hunziker P, "et al." |title=Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26597–604 |year= 2001 |pmid= 11350968 |doi= 10.1074/jbc.M102534200
*cite journal | author=Onishi-Haraikawa Y, Funaki M, Gotoh N, "et al." |title=Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 2 |pages= 476–82 |year= 2001 |pmid= 11606067 |doi= 10.1006/bbrc.2001.5791
*cite journal | author=Porjesz B, Almasy L, Edenberg HJ, "et al." |title=Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3729–33 |year= 2002 |pmid= 11891318 |doi= 10.1073/pnas.052716399
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brandon NJ, Jovanovic JN, Colledge M, "et al." |title=A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. |journal=Mol. Cell. Neurosci. |volume=22 |issue= 1 |pages= 87–97 |year= 2003 |pmid= 12595241 |doi=
*cite journal | author=Buckley ST, Dodd PR |title=GABAA receptor beta subunit mRNA expression in the human alcoholic brain. |journal=Neurochem. Int. |volume=45 |issue= 7 |pages= 1011–20 |year= 2004 |pmid= 15337300 |doi= 10.1016/j.neuint.2004.05.009

External links

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