COP9 signalosome complex subunit 3

COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis), also known as COPS3, is a human gene.cite web | title = Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8533| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.cite web | title = Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8533| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029–33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029
*cite journal | author=van Dartel M, Hulsebos TJ |title=Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. |journal=Cancer Genet. Cytogenet. |volume=153 |issue= 1 |pages= 77–80 |year= 2004 |pmid= 15325100 |doi= 10.1016/j.cancergencyto.2004.03.007
*cite journal | author=Seeger M, Kraft R, Ferrell K, "et al." |title=A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. |journal=FASEB J. |volume=12 |issue= 6 |pages= 469–78 |year= 1998 |pmid= 9535219 |doi=
*cite journal | author=Wei N, Tsuge T, Serino G, "et al." |title=The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 919–22 |year= 1998 |pmid= 9707402 |doi=
*cite journal | author=Potocki L, Chen KS, Lupski JR |title=Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2. |journal=Genomics |volume=57 |issue= 1 |pages= 180–2 |year= 1999 |pmid= 10191102 |doi= 10.1006/geno.1998.5748
*cite journal | author=Bianchi E, Denti S, Granata A, "et al." |title=Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. |journal=Nature |volume=404 |issue= 6778 |pages= 617–21 |year= 2000 |pmid= 10766246 |doi= 10.1038/35007098
*cite journal | author=Tsuge T, Matsui M, Wei N |title=The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. |journal=J. Mol. Biol. |volume=305 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11114242 |doi= 10.1006/jmbi.2000.4288
*cite journal | author=Bech-Otschir D, Kraft R, Huang X, "et al." |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630–9 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630
*cite journal | author=Lyapina S, Cope G, Shevchenko A, "et al." |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382–5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780
*cite journal | author=Hong X, Xu L, Li X, "et al." |title=CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation. |journal=FEBS Lett. |volume=499 |issue= 1-2 |pages= 133–6 |year= 2001 |pmid= 11418127 |doi=
*cite journal | author=Bi W, Yan J, Stankiewicz P, "et al." |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702
*cite journal | author=Hoareau Alves K, Bochard V, Réty S, Jalinot P |title=Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 15–21 |year= 2002 |pmid= 12220626 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Petersen HH, Hilpert J, Militz D, "et al." |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. |journal=J. Cell. Sci. |volume=116 |issue= Pt 3 |pages= 453–61 |year= 2003 |pmid= 12508107 |doi=
*cite journal | author=Serino G, Su H, Peng Z, "et al." |title=Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. |journal=Plant Cell |volume=15 |issue= 3 |pages= 719–31 |year= 2003 |pmid= 12615944 |doi=
*cite journal | author=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=
*cite journal | author=Uhle S, Medalia O, Waldron R, "et al." |title=Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1302–12 |year= 2003 |pmid= 12628923 |doi= 10.1093/emboj/cdg127
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Groisman R, Polanowska J, Kuraoka I, "et al." |title=The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. |journal=Cell |volume=113 |issue= 3 |pages= 357–67 |year= 2003 |pmid= 12732143 |doi=
*cite journal | author=Henriksen J, Aagesen TH, Maelandsmo GM, "et al." |title=Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. |journal=Oncogene |volume=22 |issue= 34 |pages= 5358–61 |year= 2003 |pmid= 12917637 |doi= 10.1038/sj.onc.1206671

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