SIX1

SIX1

Sine oculis homeobox homolog 1 (Drosophila), also known as SIX1, is a human gene.cite web | title = Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6495| accessdate = ]

PBB_Summary
section_title =
summary_text = The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues. [supplied by OMIM] cite web | title = Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6495| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Oliver G, Wehr R, Jenkins NA, "et al." |title=Homeobox genes and connective tissue patterning. |journal=Development |volume=121 |issue= 3 |pages= 693–705 |year= 1995 |pmid= 7720577 |doi=
*cite journal | author=Boucher CA, Carey N, Edwards YH, "et al." |title=Cloning of the human SIX1 gene and its assignment to chromosome 14. |journal=Genomics |volume=33 |issue= 1 |pages= 140–2 |year= 1996 |pmid= 8617500 |doi= 10.1006/geno.1996.0172
*cite journal | author=Ford HL, Kabingu EN, Bump EA, "et al." |title=Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12608–13 |year= 1998 |pmid= 9770533 |doi=
*cite journal | author=Salam AA, Häfner FM, Linder TE, "et al." |title=A novel locus (DFNA23) for prelingual autosomal dominant nonsyndromic hearing loss maps to 14q21-q22 in a Swiss German kindred. |journal=Am. J. Hum. Genet. |volume=66 |issue= 6 |pages= 1984–8 |year= 2001 |pmid= 10777717 |doi=
*cite journal | author=Ford HL, Landesman-Bollag E, Dacwag CS, "et al." |title=Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22245–54 |year= 2000 |pmid= 10801845 |doi= 10.1074/jbc.M002446200
*cite journal | author=Fan X, Brass LF, Poncz M, "et al." |title=The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32129–34 |year= 2000 |pmid= 10906137 |doi= 10.1074/jbc.M004577200
*cite journal | author=Buller C, Xu X, Marquis V, "et al." |title=Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. |journal=Hum. Mol. Genet. |volume=10 |issue= 24 |pages= 2775–81 |year= 2002 |pmid= 11734542 |doi=
*cite journal | author=Li CM, Guo M, Borczuk A, "et al." |title=Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. |journal=Am. J. Pathol. |volume=160 |issue= 6 |pages= 2181–90 |year= 2002 |pmid= 12057921 |doi=
*cite journal | author=Ikeda K, Watanabe Y, Ohto H, Kawakami K |title=Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. |journal=Mol. Cell. Biol. |volume=22 |issue= 19 |pages= 6759–66 |year= 2002 |pmid= 12215533 |doi=
*cite journal | author=López-Ríos J, Tessmar K, Loosli F, "et al." |title=Six3 and Six6 activity is modulated by members of the groucho family. |journal=Development |volume=130 |issue= 1 |pages= 185–95 |year= 2003 |pmid= 12441302 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ruf RG, Berkman J, Wolf MT, "et al." |title=A gene locus for branchio-otic syndrome maps to chromosome 14q21.3-q24.3. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= 515–9 |year= 2003 |pmid= 12843324 |doi=
*cite journal | author=Zheng W, Huang L, Wei ZB, "et al." |title=The role of Six1 in mammalian auditory system development. |journal=Development |volume=130 |issue= 17 |pages= 3989–4000 |year= 2003 |pmid= 12874121 |doi=
*cite journal | author=Li X, Oghi KA, Zhang J, "et al." |title=Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. |journal=Nature |volume=426 |issue= 6964 |pages= 247–54 |year= 2003 |pmid= 14628042 |doi= 10.1038/nature02083
*cite journal | author=Coletta RD, Christensen K, Reichenberger KJ, "et al." |title=The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 17 |pages= 6478–83 |year= 2004 |pmid= 15123840 |doi= 10.1073/pnas.0401139101
*cite journal | author=Ruf RG, Xu PX, Silvius D, "et al." |title=SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 21 |pages= 8090–5 |year= 2004 |pmid= 15141091 |doi= 10.1073/pnas.0308475101
*cite journal | author=Grifone R, Laclef C, Spitz F, "et al." |title=Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype. |journal=Mol. Cell. Biol. |volume=24 |issue= 14 |pages= 6253–67 |year= 2004 |pmid= 15226428 |doi= 10.1128/MCB.24.14.6253-6267.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ito T, Noguchi Y, Yashima T, Kitamura K |title=SIX1 mutation associated with enlargement of the vestibular aqueduct in a patient with branchio-oto syndrome. |journal=Laryngoscope |volume=116 |issue= 5 |pages= 796–9 |year= 2006 |pmid= 16652090 |doi= 10.1097/01.mlg.0000209096.40400.96

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