RBBP8

Retinoblastoma binding protein 8, also known as RBBP8, is a human gene.cite web | title = Entrez Gene: RBBP8 retinoblastoma binding protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5932| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.cite web | title = Entrez Gene: RBBP8 retinoblastoma binding protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5932| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Deng CX, Brodie SG |title=Roles of BRCA1 and its interacting proteins. |journal=Bioessays |volume=22 |issue= 8 |pages= 728–37 |year= 2000 |pmid= 10918303 |doi= 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B |doilabel=10.1002/1521-1878(200008)22:8728::AID-BIES63.0.CO;2-B
*cite journal | author=Matoba R, Okubo K, Hori N, "et al." |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=
*cite journal | author=Schaeper U, Subramanian T, Lim L, "et al." |title=Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8549–52 |year= 1998 |pmid= 9535825 |doi=
*cite journal | author=Fusco C, Reymond A, Zervos AS |title=Molecular cloning and characterization of a novel retinoblastoma-binding protein. |journal=Genomics |volume=51 |issue= 3 |pages= 351–8 |year= 1998 |pmid= 9721205 |doi= 10.1006/geno.1998.5368
*cite journal | author=Yu X, Wu LC, Bowcock AM, "et al." |title=The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25388–92 |year= 1998 |pmid= 9738006 |doi=
*cite journal | author=Wong AK, Ormonde PA, Pero R, "et al." |title=Characterization of a carboxy-terminal BRCA1 interacting protein. |journal=Oncogene |volume=17 |issue= 18 |pages= 2279–85 |year= 1998 |pmid= 9811458 |doi= 10.1038/sj.onc.1202150
*cite journal | author=Li S, Chen PL, Subramanian T, "et al." |title=Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11334–8 |year= 1999 |pmid= 10196224 |doi=
*cite journal | author=Meloni AR, Smith EJ, Nevins JR |title=A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9574–9 |year= 1999 |pmid= 10449734 |doi=
*cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538–43 |year= 2000 |pmid= 10608806 |doi=
*cite journal | author=Yu X, Baer R |title=Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18541–9 |year= 2000 |pmid= 10764811 |doi= 10.1074/jbc.M909494199
*cite journal | author=Dick FA, Sailhamer E, Dyson NJ |title=Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3715–27 |year= 2000 |pmid= 10779361 |doi=
*cite journal | author=Fanciulli M, Bruno T, Di Padova M, "et al." |title=Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. |journal=FASEB J. |volume=14 |issue= 7 |pages= 904–12 |year= 2000 |pmid= 10783144 |doi=
*cite journal | author=Li S, Ting NS, Zheng L, "et al." |title=Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. |journal=Nature |volume=406 |issue= 6792 |pages= 210–5 |year= 2000 |pmid= 10910365 |doi= 10.1038/35018134
*cite journal | author=Zheng L, Pan H, Li S, "et al." |title=Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 757–68 |year= 2000 |pmid= 11090615 |doi=
*cite journal | author=Izutsu K, Kurokawa M, Imai Y, "et al." |title=The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. |journal=Blood |volume=97 |issue= 9 |pages= 2815–22 |year= 2001 |pmid= 11313276 |doi=
*cite journal | author=Melhuish TA, Gallo CM, Wotton D |title=TGIF2 interacts with histone deacetylase 1 and represses transcription. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32109–14 |year= 2001 |pmid= 11427533 |doi= 10.1074/jbc.M103377200
*cite journal | author=Wu-Baer F, Baer R |title=Effect of DNA damage on a BRCA1 complex. |journal=Nature |volume=414 |issue= 6859 |pages= 36 |year= 2001 |pmid= 11689934 |doi= 10.1038/35102118
*cite journal | author=Sum EY, Peng B, Yu X, "et al." |title=The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7849–56 |year= 2002 |pmid= 11751867 |doi= 10.1074/jbc.M110603200
*cite journal | author=Koipally J, Georgopoulos K |title=Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23143–9 |year= 2002 |pmid= 11959865 |doi= 10.1074/jbc.M202079200

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