ARFGAP1

ADP-ribosylation factor GTPase activating protein 1, also known as ARFGAP1, is a human gene.cite web | title = Entrez Gene: ARFGAP1 ADP-ribosylation factor GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55738| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: ARFGAP1 ADP-ribosylation factor GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55738| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rothman JE |title=Mechanisms of intracellular protein transport. |journal=Nature |volume=372 |issue= 6501 |pages= 55–63 |year= 1994 |pmid= 7969419 |doi= 10.1038/372055a0
*cite journal | author=Bernards A, Settleman J |title=GAP control: regulating the regulators of small GTPases. |journal=Trends Cell Biol. |volume=14 |issue= 7 |pages= 377–85 |year= 2005 |pmid= 15246431 |doi= 10.1016/j.tcb.2004.05.003
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Cukierman E, Huber I, Rotman M, Cassel D |title=The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. |journal=Science |volume=270 |issue= 5244 |pages= 1999–2002 |year= 1996 |pmid= 8533093 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Aoe T, Cukierman E, Lee A, "et al." |title=The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1. |journal=EMBO J. |volume=16 |issue= 24 |pages= 7305–16 |year= 1998 |pmid= 9405360 |doi= 10.1093/emboj/16.24.7305
*cite journal | author=Mossessova E, Gulbis JM, Goldberg J |title=Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase. |journal=Cell |volume=92 |issue= 3 |pages= 415–23 |year= 1998 |pmid= 9476900 |doi=
*cite journal | author=Huber I, Cukierman E, Rotman M, "et al." |title=Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24786–91 |year= 1998 |pmid= 9733781 |doi=
*cite journal | author=Zhang C, Yu Y, Zhang S, "et al." |title=Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family. |journal=Genomics |volume=63 |issue= 3 |pages= 400–8 |year= 2000 |pmid= 10704287 |doi= 10.1006/geno.1999.6095
*cite journal | author=Huber I, Rotman M, Pick E, "et al." |title=Expression, purification, and properties of ADP-ribosylation factor (ARF) GTPase activating protein-1. |journal=Meth. Enzymol. |volume=329 |issue= |pages= 307–16 |year= 2001 |pmid= 11210549 |doi=
*cite journal | author=Majoul I, Straub M, Hell SW, "et al." |title=KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. |journal=Dev. Cell |volume=1 |issue= 1 |pages= 139–53 |year= 2001 |pmid= 11703931 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Yu S, Roth MG |title=Casein kinase I regulates membrane binding by ARF GAP1. |journal=Mol. Biol. Cell |volume=13 |issue= 8 |pages= 2559–70 |year= 2003 |pmid= 12181329 |doi= 10.1091/mbc.E02-04-0189
*cite journal | author=Yang JS, Lee SY, Gao M, "et al." |title=ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. |journal=J. Cell Biol. |volume=159 |issue= 1 |pages= 69–78 |year= 2002 |pmid= 12379802 |doi= 10.1083/jcb.200206015
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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