MEST (gene)

MEST (gene)

Mesoderm specific transcript homolog (mouse), also known as MEST, is a human gene.cite web | title = Entrez Gene: MEST mesoderm specific transcript homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4232| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the [alpha] / [beta] hydrolase fold family and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.cite web | title = Entrez Gene: MEST mesoderm specific transcript homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4232| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nishita Y, Yoshida I, Sado T, Takagi N |title=Genomic imprinting and chromosomal localization of the human MEST gene. |journal=Genomics |volume=36 |issue= 3 |pages= 539–42 |year= 1997 |pmid= 8884280 |doi= 10.1006/geno.1996.0502
*cite journal | author=Kobayashi S, Kohda T, Miyoshi N, "et al." |title=Human PEG1/MEST, an imprinted gene on chromosome 7. |journal=Hum. Mol. Genet. |volume=6 |issue= 5 |pages= 781–6 |year= 1997 |pmid= 9158153 |doi=
*cite journal | author=Riesewijk AM, Hu L, Schulz U, "et al." |title=Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses. |journal=Genomics |volume=42 |issue= 2 |pages= 236–44 |year= 1997 |pmid= 9192843 |doi= 10.1006/geno.1997.4731
*cite journal | author=Cuisset L, Le Stunff C, Dupont JM, "et al." |title=PEG1 expression in maternal uniparental disomy 7. |journal=Ann. Genet. |volume=40 |issue= 4 |pages= 211–5 |year= 1998 |pmid= 9526615 |doi=
*cite journal | author=Riesewijk AM, Blagitko N, Schinzel AA, "et al." |title=Evidence against a major role of PEG1/MEST in Silver-Russell syndrome. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 2 |pages= 114–20 |year= 1998 |pmid= 9781054 |doi= 10.1038/sj.ejhg.5200164
*cite journal | author=Pedersen IS, Dervan PA, Broderick D, "et al." |title=Frequent loss of imprinting of PEG1/MEST in invasive breast cancer. |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5449–51 |year= 1999 |pmid= 10554015 |doi=
*cite journal | author=Kosaki K, Kosaki R, Craigen WJ, Matsuo N |title=Isoform-specific imprinting of the human PEG1/MEST gene. |journal=Am. J. Hum. Genet. |volume=66 |issue= 1 |pages= 309–12 |year= 2000 |pmid= 10631159 |doi=
*cite journal | author=Mayer W, Hemberger M, Frank HG, "et al." |title=Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis. |journal=Dev. Dyn. |volume=217 |issue= 1 |pages= 1–10 |year= 2000 |pmid= 10679925 |doi= 10.1002/(SICI)1097-0177(200001)217:1<1::AID-DVDY1>3.0.CO;2-4 |doilabel=10.1002/(SICI)1097-0177(200001)217:11::AID-DVDY13.0.CO;2-4
*cite journal | author=Hayashida S, Yamasaki K, Asada Y, "et al." |title=Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. |journal=Genomics |volume=66 |issue= 2 |pages= 221–5 |year= 2000 |pmid= 10860668 |doi= 10.1006/geno.2000.6206
*cite journal | author=Russo S, Bedeschi MF, Cogliati F, "et al." |title=Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression. |journal=Clin. Dysmorphol. |volume=9 |issue= 3 |pages= 157–62 |year= 2000 |pmid= 10955473 |doi=
*cite journal | author=Kerjean A, Dupont JM, Vasseur C, "et al." |title=Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis. |journal=Hum. Mol. Genet. |volume=9 |issue= 14 |pages= 2183–7 |year= 2000 |pmid= 10958657 |doi=
*cite journal | author=Kohda M, Hoshiya H, Katoh M, "et al." |title=Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma. |journal=Mol. Carcinog. |volume=31 |issue= 4 |pages= 184–91 |year= 2001 |pmid= 11536368 |doi=
*cite journal | author=Miozzo M, Grati FR, Bulfamante G, "et al." |title=Post-zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1/MEST expression. |journal=Placenta |volume=22 |issue= 10 |pages= 813–21 |year= 2002 |pmid= 11718568 |doi= 10.1053/plac.2001.0728
*cite journal | author=Kobayashi S, Uemura H, Kohda T, "et al." |title=No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients. |journal=Am. J. Med. Genet. |volume=104 |issue= 3 |pages= 225–31 |year= 2002 |pmid= 11754049 |doi=
*cite journal | author=Li T, Vu TH, Lee KO, "et al." |title=An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13518–27 |year= 2002 |pmid= 11821432 |doi= 10.1074/jbc.M200458200
*cite journal | author=Bonora E, Bacchelli E, Levy ER, "et al." |title=Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. |journal=Mol. Psychiatry |volume=7 |issue= 3 |pages= 289–301 |year= 2002 |pmid= 11920156 |doi= 10.1038/sj.mp.4001004
*cite journal | author=Pedersen IS, Dervan P, McGoldrick A, "et al." |title=Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer. |journal=Hum. Mol. Genet. |volume=11 |issue= 12 |pages= 1449–53 |year= 2002 |pmid= 12023987 |doi=
*cite journal | author=Nakabayashi K, Bentley L, Hitchins MP, "et al." |title=Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. |journal=Hum. Mol. Genet. |volume=11 |issue= 15 |pages= 1743–56 |year= 2003 |pmid= 12095916 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423

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