CPA4 (gene)

Carboxypeptidase A4, also known as CPA4, is a human gene.cite web | title = Entrez Gene: CPA4 carboxypeptidase A4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51200| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.cite web | title = Entrez Gene: CPA4 carboxypeptidase A4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51200| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Huang H, Reed CP, Zhang JS, "et al." |title=Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. |journal=Cancer Res. |volume=59 |issue= 12 |pages= 2981–8 |year= 1999 |pmid= 10383164 |doi=
*cite journal | author=Hayashida S, Yamasaki K, Asada Y, "et al." |title=Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. |journal=Genomics |volume=66 |issue= 2 |pages= 221–5 |year= 2000 |pmid= 10860668 |doi= 10.1006/geno.2000.6206
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kayashima T, Yamasaki K, Yamada T, "et al." |title=The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain. |journal=Hum. Genet. |volume=112 |issue= 3 |pages= 220–6 |year= 2003 |pmid= 12552318 |doi= 10.1007/s00439-002-0891-3
*cite journal | author=Bentley L, Nakabayashi K, Monk D, "et al." |title=The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome. |journal=J. Med. Genet. |volume=40 |issue= 4 |pages= 249–56 |year= 2003 |pmid= 12676894 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=García-Castellanos R, Bonet-Figueredo R, Pallarés I, "et al." |title=Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 17 |pages= 1996–2014 |year= 2005 |pmid= 16091843 |doi= 10.1007/s00018-005-5174-4

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