RAB8A

RAB8A, member RAS oncogene family, also known as RAB8A, is a human gene.cite web | title = Entrez Gene: RAB8A RAB8A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4218| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.cite web | title = Entrez Gene: RAB8A RAB8A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4218| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Newport J, Roemer MI |title=Comparative perinatal mortality under medical care foundations and other delivery models. |journal=Inquiry : a journal of medical care organization, provision and financing |volume=12 |issue= 1 |pages= 10–7 |year= 1975 |pmid= 123217 |doi=
*cite journal | author=Nimmo ER, Sanders PG, Padua RA, "et al." |title=The MEL gene: a new member of the RAB/YPT class of RAS-related genes. |journal=Oncogene |volume=6 |issue= 8 |pages= 1347–51 |year= 1991 |pmid= 1886711 |doi=
*cite journal | author=Nimmo E, Padua RA, Hughes D, "et al." |title=Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping. |journal=Hum. Genet. |volume=81 |issue= 4 |pages= 382–4 |year= 1989 |pmid= 2564840 |doi=
*cite journal | author=Zahraoui A, Joberty G, Arpin M, "et al." |title=A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. |journal=J. Cell Biol. |volume=124 |issue= 1-2 |pages= 101–15 |year= 1994 |pmid= 8294494 |doi=
*cite journal | author=Joberty G, Tavitian A, Zahraoui A |title=Isoprenylation of Rab proteins possessing a C-terminal CaaX motif. |journal=FEBS Lett. |volume=330 |issue= 3 |pages= 323–8 |year= 1993 |pmid= 8375503 |doi=
*cite journal | author=Huber LA, Pimplikar S, Parton RG, "et al." |title=Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. |journal=J. Cell Biol. |volume=123 |issue= 1 |pages= 35–45 |year= 1993 |pmid= 8408203 |doi=
*cite journal | author=Ren M, Zeng J, De Lemos-Chiarandini C, "et al." |title=In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 5151–5 |year= 1996 |pmid= 8643544 |doi=
*cite journal | author=Bähler M, Kehrer I, Gordon L, "et al." |title=Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1. |journal=Genomics |volume=43 |issue= 1 |pages= 107–9 |year= 1997 |pmid= 9226381 |doi= 10.1006/geno.1997.4776
*cite journal | author=Wilson AL, Erdman RA, Castellano F, Maltese WA |title=Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases. |journal=Biochem. J. |volume=333 ( Pt 3) |issue= |pages= 497–504 |year= 1998 |pmid= 9677305 |doi=
*cite journal | author=Bao S, Zhu J, Garvey WT |title=Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects. |journal=Horm. Metab. Res. |volume=30 |issue= 11 |pages= 656–62 |year= 1999 |pmid= 9918381 |doi=
*cite journal | author=Shisheva A, Chinni SR, DeMarco C |title=General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. |journal=Biochemistry |volume=38 |issue= 36 |pages= 11711–21 |year= 1999 |pmid= 10512627 |doi=
*cite journal | author=Hattula K, Peränen J |title=FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. |journal=Curr. Biol. |volume=10 |issue= 24 |pages= 1603–6 |year= 2001 |pmid= 11137014 |doi=
*cite journal | author=Kuroda TS, Fukuda M, Ariga H, Mikoshiba K |title=The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9212–8 |year= 2002 |pmid= 11773082 |doi= 10.1074/jbc.M112414200
*cite journal | author=Hattula K, Furuhjelm J, Arffman A, Peränen J |title=A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3268–80 |year= 2003 |pmid= 12221131 |doi= 10.1091/mbc.E02-03-0143
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373–80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200
*cite journal | author=Lau AS, Mruk DD |title=Rab8B GTPase and junction dynamics in the testis. |journal=Endocrinology |volume=144 |issue= 4 |pages= 1549–63 |year= 2003 |pmid= 12639940 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Linder MD, Uronen RL, Hölttä-Vuori M, "et al." |title=Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. |journal=Mol. Biol. Cell |volume=18 |issue= 1 |pages= 47–56 |year= 2007 |pmid= 17050734 |doi= 10.1091/mbc.E06-07-0575

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