FGF9

FGF9

Fibroblast growth factor 9 (glia-activating factor), also known as FGF9, is a human gene.cite web | title = Entrez Gene: FGF9 fibroblast growth factor 9 (glia-activating factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2254| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis.cite web | title = Entrez Gene: FGF9 fibroblast growth factor 9 (glia-activating factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2254| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Miyamoto M, Naruo K, Seko C, "et al." |title=Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. |journal=Mol. Cell. Biol. |volume=13 |issue= 7 |pages= 4251–9 |year= 1993 |pmid= 8321227 |doi=
*cite journal | author=Naruo K, Seko C, Kuroshima K, "et al." |title=Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2857–64 |year= 1993 |pmid= 8428960 |doi=
*cite journal | author=Mattei MG, Penault-Llorca F, Coulier F, Birnbaum D |title=The human FGF9 gene maps to chromosomal region 13q11-q12. |journal=Genomics |volume=29 |issue= 3 |pages= 811–2 |year= 1996 |pmid= 8575785 |doi= 10.1006/geno.1995.9926
*cite journal | author=Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM |title=Expression and biological activity of mouse fibroblast growth factor-9. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1726–31 |year= 1996 |pmid= 8576175 |doi=
*cite journal | author=Ornitz DM, Xu J, Colvin JS, "et al." |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292–7 |year= 1996 |pmid= 8663044 |doi=
*cite journal | author=Nakamura S, Todo T, Haga S, "et al." |title=Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9. |journal=Neurosci. Lett. |volume=221 |issue= 2-3 |pages= 181–4 |year= 1997 |pmid= 9121694 |doi=
*cite journal | author=Todo T, Kondo T, Nakamura S, "et al." |title=Neuronal localization of fibroblast growth factor-9 immunoreactivity in human and rat brain. |journal=Brain Res. |volume=783 |issue= 2 |pages= 179–87 |year= 1998 |pmid= 9507114 |doi=
*cite journal | author=Giri D, Ropiquet F, Ittmann M |title=FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells. |journal=J. Cell. Physiol. |volume=180 |issue= 1 |pages= 53–60 |year= 1999 |pmid= 10362017 |doi= 10.1002/(SICI)1097-4652(199907)180:1<53::AID-JCP6>3.0.CO;2-P |doilabel=10.1002/(SICI)1097-4652(199907)180:153::AID-JCP63.0.CO;2-P
*cite journal | author=Klein RD, Maliner-Jongewaard MS, Udayakumar TS, "et al." |title=Promatrilysin expression is induced by fibroblast growth factors in the prostatic carcinoma cell line LNCaP but not in normal primary prostate epithelial cells. |journal=Prostate |volume=41 |issue= 4 |pages= 215–23 |year= 1999 |pmid= 10544294 |doi=
*cite journal | author=Chellaiah A, Yuan W, Chellaiah M, Ornitz DM |title=Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34785–94 |year= 2000 |pmid= 10574949 |doi=
*cite journal | author=Plotnikov AN, Eliseenkova AV, Ibrahimi OA, "et al." |title=Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4322–9 |year= 2001 |pmid= 11060292 |doi= 10.1074/jbc.M006502200
*cite journal | author=Hecht HJ, Adar R, Hofmann B, "et al." |title=Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=57 |issue= Pt 3 |pages= 378–84 |year= 2001 |pmid= 11223514 |doi=
*cite journal | author=Tsai SJ, Wu MH, Chen HM, "et al." |title=Fibroblast growth factor-9 is an endometrial stromal growth factor. |journal=Endocrinology |volume=143 |issue= 7 |pages= 2715–21 |year= 2002 |pmid= 12072406 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Alizadeh M, Miyamura N, Handa JT, Hjelmeland LM |title=Human RPE cells express the FGFR2IIIc and FGFR3IIIc splice variants and FGF9 as a potential high affinity ligand. |journal=Exp. Eye Res. |volume=76 |issue= 2 |pages= 249–56 |year= 2003 |pmid= 12565813 |doi=
*cite journal | author=Wing LY, Chuang PC, Wu MH, "et al." |title=Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 11 |pages= 5547–54 |year= 2003 |pmid= 14602803 |doi=
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fakhry A, Ratisoontorn C, Vedhachalam C, "et al." |title=Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential. |journal=Bone |volume=36 |issue= 2 |pages= 254–66 |year= 2005 |pmid= 15780951 |doi= 10.1016/j.bone.2004.10.003

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