ANTXR1

Anthrax toxin receptor 1, also known as ANTXR1, is a human gene.cite web | title = Entrez Gene: ANTXR1 anthrax toxin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84168| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.cite web | title = Entrez Gene: ANTXR1 anthrax toxin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84168| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Schmidt DR, Schreiber SL |title=Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. |journal=Biochemistry |volume=38 |issue= 44 |pages= 14711–7 |year= 1999 |pmid= 10545197 |doi=
*cite journal | author=St Croix B, Rago C, Velculescu V, "et al." |title=Genes expressed in human tumor endothelium. |journal=Science |volume=289 |issue= 5482 |pages= 1197–202 |year= 2000 |pmid= 10947988 |doi=
*cite journal | author=Carson-Walter EB, Watkins DN, Nanda A, "et al." |title=Cell surface tumor endothelial markers are conserved in mice and humans. |journal=Cancer Res. |volume=61 |issue= 18 |pages= 6649–55 |year= 2001 |pmid= 11559528 |doi=
*cite journal | author=Liu XH, Collier RJ, Youle RJ |title=Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46326–32 |year= 2002 |pmid= 11574549 |doi= 10.1074/jbc.M108930200
*cite journal | author=Bradley KA, Mogridge J, Mourez M, "et al." |title=Identification of the cellular receptor for anthrax toxin. |journal=Nature |volume=414 |issue= 6860 |pages= 225–9 |year= 2001 |pmid= 11700562 |doi= 10.1038/n35101999
*cite journal | author=Latonen L, Taya Y, Laiho M |title=UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. |journal=Oncogene |volume=20 |issue= 46 |pages= 6784–93 |year= 2001 |pmid= 11709713 |doi= 10.1038/sj.onc.1204883
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scobie HM, Rainey GJ, Bradley KA, Young JA |title=Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 9 |pages= 5170–4 |year= 2003 |pmid= 12700348 |doi= 10.1073/pnas.0431098100
*cite journal | author=Bradley KA, Mogridge J, Jonah G, "et al." |title=Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49342–7 |year= 2004 |pmid= 14507921 |doi= 10.1074/jbc.M307900200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jones GG, Reaper PM, Pettitt AR, Sherrington PD |title=The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes. |journal=Oncogene |volume=23 |issue= 10 |pages= 1911–21 |year= 2004 |pmid= 14755251 |doi= 10.1038/sj.onc.1207318
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bonuccelli G, Sotgia F, Frank PG, "et al." |title=ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection. |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 6 |pages= C1402–10 |year= 2005 |pmid= 15689409 |doi= 10.1152/ajpcell.00582.2004
*cite journal | author=Hotchkiss KA, Basile CM, Spring SC, "et al." |title=TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen. |journal=Exp. Cell Res. |volume=305 |issue= 1 |pages= 133–44 |year= 2005 |pmid= 15777794 |doi= 10.1016/j.yexcr.2004.12.025
*cite journal | author=Rmali KA, Puntis MC, Jiang WG |title=TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 1 |pages= 231–8 |year= 2005 |pmid= 15993844 |doi= 10.1016/j.bbrc.2005.06.085
*cite journal | author=Rainey GJ, Wigelsworth DJ, Ryan PL, "et al." |title=Receptor-specific requirements for anthrax toxin delivery into cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13278–83 |year= 2005 |pmid= 16141341 |doi= 10.1073/pnas.0505865102
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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