LGI1

Leucine-rich, glioma inactivated 1, also known as LGI1, is a human gene. It may be a metastasis suppressor.

PBB_Summary
section_title =
summary_text = The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas.cite web | title = Entrez Gene: LGI1 leucine-rich, glioma inactivated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9211| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Staub E, Pérez-Tur J, Siebert R, "et al." |title=The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. |journal=Trends Biochem. Sci. |volume=27 |issue= 9 |pages= 441–4 |year= 2002 |pmid= 12217514 |doi=10.1016/S0968-0004(02)02163-1
*cite journal | author=Gu W, Brodtkorb E, Piepoli T, "et al." |title=LGI1: a gene involved in epileptogenesis and glioma progression? |journal=Neurogenetics |volume=6 |issue= 2 |pages= 59–66 |year= 2005 |pmid= 15827762 |doi= 10.1007/s10048-005-0216-5
*cite journal | author=Ottman R, Risch N, Hauser WA, "et al." |title=Localization of a gene for partial epilepsy to chromosome 10q. |journal=Nat. Genet. |volume=10 |issue= 1 |pages= 56–60 |year= 1995 |pmid= 7647791 |doi= 10.1038/ng0595-56
*cite journal | author=Chernova OB, Somerville RP, Cowell JK |title=A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. |journal=Oncogene |volume=17 |issue= 22 |pages= 2873–81 |year= 1999 |pmid= 9879993 |doi= 10.1038/sj.onc.1202481
*cite journal | author=Kalachikov S, Evgrafov O, Ross B, "et al." |title=Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. |journal=Nat. Genet. |volume=30 |issue= 3 |pages= 335–41 |year= 2002 |pmid= 11810107 |doi= 10.1038/ng832
*cite journal | author=Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S, "et al." |title=Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. |journal=Hum. Mol. Genet. |volume=11 |issue= 9 |pages= 1119–28 |year= 2002 |pmid= 11978770 |doi=10.1093/hmg/11.9.1119
*cite journal | author=Scheel H, Tomiuk S, Hofmann K |title=A common protein interaction domain links two recently identified epilepsy genes. |journal=Hum. Mol. Genet. |volume=11 |issue= 15 |pages= 1757–62 |year= 2003 |pmid= 12095917 |doi=10.1093/hmg/11.15.1757
*cite journal | author=Gu W, Brodtkorb E, Steinlein OK |title=LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. |journal=Ann. Neurol. |volume=52 |issue= 3 |pages= 364–7 |year= 2002 |pmid= 12205652 |doi= 10.1002/ana.10280
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pizzuti A, Flex E, Di Bonaventura C, "et al." |title=Epilepsy with auditory features: an LGI1 gene mutation suggests a loss-of-function mechanism. |journal=Ann. Neurol. |volume=53 |issue= 3 |pages= 396–9 |year= 2003 |pmid= 12601709 |doi= 10.1002/ana.10492
*cite journal | author=Fertig E, Lincoln A, Martinuzzi A, "et al." |title=Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features. |journal=Neurology |volume=60 |issue= 10 |pages= 1687–90 |year= 2004 |pmid= 12771268 |doi=
*cite journal | author=Kunapuli P, Chitta KS, Cowell JK |title=Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene. |journal=Oncogene |volume=22 |issue= 26 |pages= 3985–91 |year= 2003 |pmid= 12821932 |doi= 10.1038/sj.onc.1206584
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Hedera P, Abou-Khalil B, Crunk AE, "et al." |title=Autosomal dominant lateral temporal epilepsy: two families with novel mutations in the LGI1 gene. |journal=Epilepsia |volume=45 |issue= 3 |pages= 218–22 |year= 2004 |pmid= 15009222 |doi=10.1111/j.0013-9580.2004.47203.x
*cite journal | author=Kunapuli P, Kasyapa CS, Hawthorn L, Cowell JK |title=LGI1, a putative tumor metastasis suppressor gene, controls "in vitro" invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway. |journal=J. Biol. Chem. |volume=279 |issue= 22 |pages= 23151–7 |year= 2004 |pmid= 15047712 |doi= 10.1074/jbc. M314192200
*cite journal | author=Berkovic SF, Izzillo P, McMahon JM, "et al." |title=LGI1 mutations in temporal lobe epilepsies. |journal=Neurology |volume=62 |issue= 7 |pages= 1115–9 |year= 2004 |pmid= 15079010 |doi=
*cite journal | author=Ottman R, Winawer MR, Kalachikov S, "et al." |title=LGI1 mutations in autosomal dominant partial epilepsy with auditory features. |journal=Neurology |volume=62 |issue= 7 |pages= 1120–6 |year= 2004 |pmid= 15079011 |doi=
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Bisulli F, Tinuper P, Scudellaro E, "et al." |title=A de novo LGI1 mutation in sporadic partial epilepsy with auditory features. |journal=Ann. Neurol. |volume=56 |issue= 3 |pages= 455–6 |year= 2004 |pmid= 15349881 |doi= 10.1002/ana.20218

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes