AMFR

Autocrine motility factor receptor, also known as AMFR, is a human gene.cite web | title = Entrez Gene: AMFR autocrine motility factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=267| accessdate = ]

PBB_Summary
section_title =
summary_text = Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.cite web | title = Entrez Gene: AMFR autocrine motility factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=267| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Watanabe H, Carmi P, Hogan V, "et al." |title=Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. |journal=J. Biol. Chem. |volume=266 |issue= 20 |pages= 13442–8 |year= 1991 |pmid= 1649192 |doi=
*cite journal | author=Huang B, Xie Y, Raz A |title=Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. |journal=Biochem. Biophys. Res. Commun. |volume=212 |issue= 3 |pages= 727–42 |year= 1995 |pmid= 7626106 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Shimizu K, Tani M, Watanabe H, "et al." |title=The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. |journal=FEBS Lett. |volume=456 |issue= 2 |pages= 295–300 |year= 1999 |pmid= 10456327 |doi=
*cite journal | author=Fang S, Ferrone M, Yang C, "et al." |title=The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 25 |pages= 14422–7 |year= 2002 |pmid= 11724934 |doi= 10.1073/pnas.251401598
*cite journal | author=Luo Y, Long JM, Lu C, "et al." |title=A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. |journal=J. Neurochem. |volume=80 |issue= 2 |pages= 354–61 |year= 2002 |pmid= 11902125 |doi=
*cite journal | author=Tímár J, Rásó E, Döme B, "et al." |title=Expression and function of the AMF receptor by human melanoma in experimental and clinical systems. |journal=Clin. Exp. Metastasis |volume=19 |issue= 3 |pages= 225–32 |year= 2002 |pmid= 12067203 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liang JS, Kim T, Fang S, "et al." |title=Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23984–8 |year= 2003 |pmid= 12670940 |doi= 10.1074/jbc.M302683200
*cite journal | author=Takanami I, Takeuchi K |title=Autocrine motility factor-receptor gene expression in lung cancer. |journal=Jpn. J. Thorac. Cardiovasc. Surg. |volume=51 |issue= 8 |pages= 368–73 |year= 2003 |pmid= 12962414 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Registre M, Goetz JG, St Pierre P, "et al." |title=The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 4 |pages= 1316–22 |year= 2004 |pmid= 15303277 |doi=
*cite journal | author=Zhong X, Shen Y, Ballar P, "et al." |title=AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 45676–84 |year= 2004 |pmid= 15331598 |doi= 10.1074/jbc.M409034200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Song BL, Sever N, DeBose-Boyd RA |title=Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. |journal=Mol. Cell |volume=19 |issue= 6 |pages= 829–40 |year= 2005 |pmid= 16168377 |doi= 10.1016/j.molcel.2005.08.009
*cite journal | author=Kaynak K, Kara M, Oz B, "et al." |title=Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas. |journal=Acta Chir. Belg. |volume=105 |issue= 4 |pages= 378–82 |year= 2006 |pmid= 16184720 |doi=
*cite journal | author=Ye Y, Shibata Y, Kikkert M, "et al." |title=Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 40 |pages= 14132–8 |year= 2006 |pmid= 16186510 |doi= 10.1073/pnas.0505006102
*cite journal | author=Chen B, Mariano J, Tsai YC, "et al." |title=The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 2 |pages= 341–6 |year= 2006 |pmid= 16407162 |doi= 10.1073/pnas.0506618103
*cite journal | author=Haga A, Tanaka N, Funasaka T, "et al." |title=The autocrine motility factor (AMF) and AMF-receptor combination needs sugar chain recognition ability and interaction using the C-terminal region of AMF. |journal=J. Mol. Biol. |volume=358 |issue= 3 |pages= 741–53 |year= 2006 |pmid= 16563432 |doi= 10.1016/j.jmb.2006.02.046
*cite journal | author=Shen Y, Ballar P, Fang S |title=Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 4 |pages= 1285–93 |year= 2006 |pmid= 16979136 |doi= 10.1016/j.bbrc.2006.08.173

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes