GNLY

Granulysin, also known as GNLY, is a human gene.cite web | title = Entrez Gene: GNLY granulysin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10578| accessdate = ]

PBB_Summary
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summary_text = Granulysin is a protein present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells. Granulysin is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. Granulysin has antimicrobial activity against M. tuberculosis and other organisms. Granulysin is alternatively spliced, resulting in the NKG5 and 519 transcripts.cite web | title = Entrez Gene: GNLY granulysin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10578| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Peña SV, Krensky AM |title=Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity. |journal=Semin. Immunol. |volume=9 |issue= 2 |pages= 117–25 |year= 1997 |pmid= 9194222 |doi= 10.1006/smim.1997.0061
*cite journal | author=Krensky AM |title=Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. |journal=Biochem. Pharmacol. |volume=59 |issue= 4 |pages= 317–20 |year= 2000 |pmid= 10644038 |doi=
*cite journal | author=Donlon TA, Krensky AM, Clayberger C |title=Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12----q11. |journal=Cytogenet. Cell Genet. |volume=53 |issue= 4 |pages= 230–1 |year= 1990 |pmid= 2209093 |doi=
*cite journal | author=Yabe T, McSherry C, Bach FH, Houchins JP |title=A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. |journal=J. Exp. Med. |volume=172 |issue= 4 |pages= 1159–63 |year= 1990 |pmid= 2212946 |doi=
*cite journal | author=Jongstra J, Schall TJ, Dyer BJ, "et al." |title=The isolation and sequence of a novel gene from a human functional T cell line. |journal=J. Exp. Med. |volume=165 |issue= 3 |pages= 601–14 |year= 1987 |pmid= 2434598 |doi=
*cite journal | author=Houchins JP, Kricek F, Chujor CS, "et al." |title=Genomic structure of NKG5, a human NK and T cell-specific activation gene. |journal=Immunogenetics |volume=37 |issue= 2 |pages= 102–7 |year= 1993 |pmid= 8423048 |doi=
*cite journal | author=Peña SV, Hanson DA, Carr BA, "et al." |title=Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2680–8 |year= 1997 |pmid= 9058801 |doi=
*cite journal | author=Stenger S, Hanson DA, Teitelbaum R, "et al." |title=An antimicrobial activity of cytolytic T cells mediated by granulysin. |journal=Science |volume=282 |issue= 5386 |pages= 121–5 |year= 1998 |pmid= 9756476 |doi=
*cite journal | author=Hanson DA, Kaspar AA, Poulain FR, Krensky AM |title=Biosynthesis of granulysin, a novel cytolytic molecule. |journal=Mol. Immunol. |volume=36 |issue= 7 |pages= 413–22 |year= 1999 |pmid= 10449094 |doi=
*cite journal | author=Kaspar AA, Okada S, Kumar J, "et al." |title=A distinct pathway of cell-mediated apoptosis initiated by granulysin. |journal=J. Immunol. |volume=167 |issue= 1 |pages= 350–6 |year= 2001 |pmid= 11418670 |doi=
*cite journal | author=Kitamura N, Koshiba M, Horie O, Ryo R |title=Expression of granulysin mRNA in the human megakaryoblastic leukemia cell line CMK. |journal=Acta Haematol. |volume=108 |issue= 1 |pages= 13–8 |year= 2002 |pmid= 12145461 |doi=
*cite journal | author=Ma LL, Spurrell JC, Wang JF, "et al." |title=CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15. |journal=J. Immunol. |volume=169 |issue= 10 |pages= 5787–95 |year= 2003 |pmid= 12421959 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ericson KG, Fadeel B, Andersson M, "et al." |title=Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis. |journal=Hum. Genet. |volume=112 |issue= 1 |pages= 98–9 |year= 2003 |pmid= 12483306 |doi= 10.1007/s00439-002-0841-0
*cite journal | author=Anderson DH, Sawaya MR, Cascio D, "et al." |title=Granulysin crystal structure and a structure-derived lytic mechanism. |journal=J. Mol. Biol. |volume=325 |issue= 2 |pages= 355–65 |year= 2003 |pmid= 12488100 |doi=
*cite journal | author=Gansert JL, Kiessler V, Engele M, "et al." |title=Human NKT cells express granulysin and exhibit antimycobacterial activity. |journal=J. Immunol. |volume=170 |issue= 6 |pages= 3154–61 |year= 2003 |pmid= 12626573 |doi=
*cite journal | author=Ogawa K, Takamori Y, Suzuki K, "et al." |title=Granulysin in human serum as a marker of cell-mediated immunity. |journal=Eur. J. Immunol. |volume=33 |issue= 7 |pages= 1925–33 |year= 2003 |pmid= 12884856 |doi= 10.1002/eji.200323977
*cite journal | author=Kotsch K, Mashreghi MF, Bold G, "et al." |title=Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. |journal=Transplantation |volume=77 |issue= 12 |pages= 1866–75 |year= 2004 |pmid= 15223905 |doi=

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