CHD4

Chromodomain helicase DNA binding protein 4, also known as CHD4, is a human gene.cite web | title = Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1108| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.cite web | title = Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1108| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Denslow SA, Wade PA |title=The human Mi-2/NuRD complex and gene regulation. |journal=Oncogene |volume=26 |issue= 37 |pages= 5433–8 |year= 2007 |pmid= 17694084 |doi= 10.1038/sj.onc.1210611
*cite journal | author=Ge Q, Nilasena DS, O'Brien CA, "et al." |title=Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. |journal=J. Clin. Invest. |volume=96 |issue= 4 |pages= 1730–7 |year= 1995 |pmid= 7560064 |doi=
*cite journal | author=Seelig HP, Moosbrugger I, Ehrfeld H, "et al." |title=The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. |journal=Arthritis Rheum. |volume=38 |issue= 10 |pages= 1389–99 |year= 1995 |pmid= 7575689 |doi=
*cite journal | author=Seelig HP, Renz M, Targoff IN, "et al." |title=Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen. |journal=Arthritis Rheum. |volume=39 |issue= 10 |pages= 1769–71 |year= 1996 |pmid= 8843877 |doi=
*cite journal | author=Woodage T, Basrai MA, Baxevanis AD, "et al." |title=Characterization of the CHD family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11472–7 |year= 1997 |pmid= 9326634 |doi=
*cite journal | author=Zhang Y, LeRoy G, Seelig HP, "et al." |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279–89 |year= 1998 |pmid= 9790534 |doi=
*cite journal | author=Tong JK, Hassig CA, Schnitzler GR, "et al." |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917–21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699
*cite journal | author=Zhang Y, Ng HH, Erdjument-Bromage H, "et al." |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924–35 |year= 1999 |pmid= 10444591 |doi=
*cite journal | author=Schmidt DR, Schreiber SL |title=Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. |journal=Biochemistry |volume=38 |issue= 44 |pages= 14711–7 |year= 1999 |pmid= 10545197 |doi=
*cite journal | author=Humphrey GW, Wang Y, Russanova VR, "et al." |title=Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6817–24 |year= 2001 |pmid= 11102443 |doi= 10.1074/jbc.M007372200
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697–705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200
*cite journal | author=Saito M, Ishikawa F |title=The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35434–9 |year= 2002 |pmid= 12124384 |doi= 10.1074/jbc.M203455200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hakimi MA, Dong Y, Lane WS, "et al." |title=A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7234–9 |year= 2003 |pmid= 12493763 |doi= 10.1074/jbc.M208992200
*cite journal | author=Kwan AH, Gell DA, Verger A, "et al." |title=Engineering a protein scaffold from a PHD finger. |journal=Structure |volume=11 |issue= 7 |pages= 803–13 |year= 2004 |pmid= 12842043 |doi=
*cite journal | author=Shimono Y, Murakami H, Kawai K, "et al." |title=Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51638–45 |year= 2004 |pmid= 14530259 |doi= 10.1074/jbc.M309198200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Williams CJ, Naito T, Arco PG, "et al." |title=The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. |journal=Immunity |volume=20 |issue= 6 |pages= 719–33 |year= 2004 |pmid= 15189737 |doi= 10.1016/j.immuni.2004.05.005
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004

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