Signal transducing adaptor molecule

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1, also known as STAM, is a human gene.cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = ]

PBB_Summary
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summary_text = This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takeshita T, Arita T, Asao H, "et al." |title=Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 3 |pages= 1035–9 |year= 1996 |pmid= 8780729 |doi= 10.1006/bbrc.1996.1290
*cite journal | author=Takeshita T, Arita T, Higuchi M, "et al." |title=STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. |journal=Immunity |volume=6 |issue= 4 |pages= 449–57 |year= 1997 |pmid= 9133424 |doi=
*cite journal | author=Asao H, Sasaki Y, Arita T, "et al." |title=Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32785–91 |year= 1998 |pmid= 9407053 |doi=
*cite journal | author=Tanaka N, Kaneko K, Asao H, "et al." |title=Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19129–35 |year= 1999 |pmid= 10383417 |doi=
*cite journal | author=Endo K, Takeshita T, Kasai H, "et al." |title=STAM2, a new member of the STAM family, binding to the Janus kinases. |journal=FEBS Lett. |volume=477 |issue= 1-2 |pages= 55–61 |year= 2000 |pmid= 10899310 |doi=
*cite journal | author=Kato M, Miyazawa K, Kitamura N |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37481–7 |year= 2001 |pmid= 10982817 |doi= 10.1074/jbc. M007251200
*cite journal | author=Pandey A, Fernandez MM, Steen H, "et al." |title=Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38633–9 |year= 2001 |pmid= 10993906 |doi= 10.1074/jbc. M007849200
*cite journal | author=Steen H, Kuster B, Fernandez M, "et al." |title=Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1031–9 |year= 2002 |pmid= 11687594 |doi= 10.1074/jbc. M109992200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bache KG, Raiborg C, Mehlum A, Stenmark H |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12513–21 |year= 2003 |pmid= 12551915 |doi= 10.1074/jbc. M210843200
*cite journal | author=Blackstone C, Roberts RG, Seeburg DP, Sheng M |title=Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 2 |pages= 345–52 |year= 2003 |pmid= 12745081 |doi=
*cite journal | author=Mizuno E, Kawahata K, Kato M, "et al." |title=STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. |journal=Mol. Biol. Cell |volume=14 |issue= 9 |pages= 3675–89 |year= 2004 |pmid= 12972556 |doi= 10.1091/mbc. E02-12-0823
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mizuno E, Kawahata K, Okamoto A, "et al." |title=Association with Hrs is required for the early endosomal localization, stability, and function of STAM. |journal=J. Biochem. |volume=135 |issue= 3 |pages= 385–96 |year= 2005 |pmid= 15113837 |doi=
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kobayashi H, Tanaka N, Asao H, "et al." |title=Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10468–77 |year= 2005 |pmid= 15640163 |doi= 10.1074/jbc. M409969200
*cite journal | author=Row PE, Clague MJ, Urbé S |title=Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. |journal=Biochem. J. |volume=389 |issue= Pt 3 |pages= 629–36 |year= 2005 |pmid= 15828871 |doi= 10.1042/BJ20050067
*cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, "et al." |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp. M500089-MCP200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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