STAM2

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, also known as STAM2, is a human gene.cite web | title = Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10254| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.cite web | title = Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10254| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sulman EP, Tang XX, Allen C, "et al." |title=ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. |journal=Genomics |volume=40 |issue= 2 |pages= 371–4 |year= 1997 |pmid= 9119409 |doi= 10.1006/geno.1996.4569
*cite journal | author=Endo K, Takeshita T, Kasai H, "et al." |title=STAM2, a new member of the STAM family, binding to the Janus kinases. |journal=FEBS Lett. |volume=477 |issue= 1-2 |pages= 55–61 |year= 2000 |pmid= 10899310 |doi=
*cite journal | author=Kato M, Miyazawa K, Kitamura N |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37481–7 |year= 2001 |pmid= 10982817 |doi= 10.1074/jbc.M007251200
*cite journal | author=Pandey A, Fernandez MM, Steen H, "et al." |title=Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38633–9 |year= 2001 |pmid= 10993906 |doi= 10.1074/jbc.M007849200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Steen H, Kuster B, Fernandez M, "et al." |title=Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1031–9 |year= 2002 |pmid= 11687594 |doi= 10.1074/jbc.M109992200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bache KG, Raiborg C, Mehlum A, Stenmark H |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12513–21 |year= 2003 |pmid= 12551915 |doi= 10.1074/jbc.M210843200
*cite journal | author=Kaneko T, Kumasaka T, Ganbe T, "et al." |title=Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48162–8 |year= 2004 |pmid= 13129930 |doi= 10.1074/jbc.M306677200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mizuno E, Kawahata K, Okamoto A, "et al." |title=Association with Hrs is required for the early endosomal localization, stability, and function of STAM. |journal=J. Biochem. |volume=135 |issue= 3 |pages= 385–96 |year= 2005 |pmid= 15113837 |doi=
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
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*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Lechner MS, Schultz DC, Negorev D, "et al." |title=The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 4 |pages= 929–37 |year= 2005 |pmid= 15882967 |doi= 10.1016/j.bbrc.2005.04.016

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