PLCE1

Phospholipase C, epsilon 1, also known as PLCE1, is a human gene.cite web | title = Entrez Gene: PLCE1 phospholipase C, epsilon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51196| accessdate = ]

PBB_Summary
section_title =
summary_text = PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression. [supplied by OMIM] cite web | title = Entrez Gene: PLCE1 phospholipase C, epsilon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51196| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jefferson JA, Shankland SJ |title=Familial nephrotic syndrome: PLCE1 enters the fray. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 7 |pages= 1849–52 |year= 2007 |pmid= 17449496 |doi= 10.1093/ndt/gfm098
*cite journal | author=Cefai D, Debre P, Kaczorek M, "et al." |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117–24 |year= 1991 |pmid= 1979339 |doi=
*cite journal | author=Zauli G, Previati M, Caramelli E, "et al." |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695–700 |year= 1995 |pmid= 7589147 |doi=
*cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=
*cite journal | author=Mayne M, Bratanich AC, Chen P, "et al." |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=
*cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363–74 |year= 1999 |pmid= 10501179 |doi=
*cite journal | author=Nagase T, Kikuno R, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=
*cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538–42 |year= 2000 |pmid= 10843712 |doi=
*cite journal | author=Lopez I, Mak EC, Ding J, "et al." |title=A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2758–65 |year= 2001 |pmid= 11022047 |doi= 10.1074/jbc.M008119200
*cite journal | author=Song C, Hu CD, Masago M, "et al." |title=Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2752–7 |year= 2001 |pmid= 11022048 |doi= 10.1074/jbc.M008324200
*cite journal | author=Jin TG, Satoh T, Liao Y, "et al." |title=Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30301–7 |year= 2001 |pmid= 11395506 |doi= 10.1074/jbc.M103530200
*cite journal | author=Schmidt M, Evellin S, Weernink PA, "et al." |title=A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. |journal=Nat. Cell Biol. |volume=3 |issue= 11 |pages= 1020–4 |year= 2001 |pmid= 11715024 |doi= 10.1038/ncb1101-1020
*cite journal | author=Evellin S, Nolte J, Tysack K, "et al." |title=Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16805–13 |year= 2002 |pmid= 11877431 |doi= 10.1074/jbc.M112024200
*cite journal | author=Song C, Satoh T, Edamatsu H, "et al." |title=Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. |journal=Oncogene |volume=21 |issue= 53 |pages= 8105–13 |year= 2002 |pmid= 12444546 |doi= 10.1038/sj.onc.1206003
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=
*cite journal | author=Czyzyk J, Brogdon JL, Badou A, "et al." |title=Activation of CD4 T cells by Raf-independent effectors of Ras. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 6003–8 |year= 2003 |pmid= 12721365 |doi= 10.1073/pnas.1031494100
*cite journal | author=Lennartsson J, Wernstedt C, Engström U, "et al." |title=Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 110–8 |year= 2003 |pmid= 12878163 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=vom Dorp F, Sari AY, Sanders H, "et al." |title=Inhibition of phospholipase C-epsilon by Gi-coupled receptors. |journal=Cell. Signal. |volume=16 |issue= 8 |pages= 921–8 |year= 2005 |pmid= 15157671 |doi= 10.1016/j.cellsig.2004.01.009

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