PPP1R15A

Protein phosphatase 1, regulatory (inhibitor) subunit 15A, also known as PPP1R15A, is a human gene.cite web | title = Entrez Gene: PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23645| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.cite web | title = Entrez Gene: PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23645| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Hollander MC, Zhan Q, Bae I, Fornace AJ |title=Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13731–7 |year= 1997 |pmid= 9153226 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Korabiowska M, Betke H, Kellner S, "et al." |title=Differential expression of growth arrest, DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas. |journal=Anticancer Res. |volume=17 |issue= 5A |pages= 3697–700 |year= 1998 |pmid= 9413226 |doi=
*cite journal | author=Hasegawa T, Isobe K |title=Evidence for the interaction between Translin and GADD34 in mammalian cells. |journal=Biochim. Biophys. Acta |volume=1428 |issue= 2-3 |pages= 161–8 |year= 1999 |pmid= 10434033 |doi=
*cite journal | author=Adler HT, Chinery R, Wu DY, "et al." |title=Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7050–60 |year= 2000 |pmid= 10490642 |doi=
*cite journal | author=Hasegawa T, Yagi A, Isobe K |title=Interaction between GADD34 and kinesin superfamily, KIF3A. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 2 |pages= 593–6 |year= 2000 |pmid= 10631107 |doi= 10.1006/bbrc.1999.1991
*cite journal | author=Hasegawa T, Xiao H, Hamajima F, Isobe K |title=Interaction between DNA-damage protein GADD34 and a new member of the Hsp40 family of heat shock proteins that is induced by a DNA-damaging reagent. |journal=Biochem. J. |volume=352 Pt 3 |issue= |pages= 795–800 |year= 2001 |pmid= 11104688 |doi=
*cite journal | author=Grishin AV, Azhipa O, Semenov I, Corey SJ |title=Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10172–7 |year= 2001 |pmid= 11517336 |doi= 10.1073/pnas.191130798
*cite journal | author=Connor JH, Weiser DC, Li S, "et al." |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6841–50 |year= 2001 |pmid= 11564868 |doi= 10.1128/MCB.21.20.6841-6850.2001
*cite journal | author=Wu DY, Tkachuck DC, Roberson RS, Schubach WH |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27706–15 |year= 2002 |pmid= 12016208 |doi= 10.1074/jbc.M200955200
*cite journal | author=Korabiowska M, Cordon-Cardo C, Betke H, "et al." |title=GADD153 is an independent prognostic factor in melanoma: immunohistochemical and molecular genetic analysis. |journal=Histol. Histopathol. |volume=17 |issue= 3 |pages= 805–11 |year= 2003 |pmid= 12168790 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brush MH, Weiser DC, Shenolikar S |title=Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. |journal=Mol. Cell. Biol. |volume=23 |issue= 4 |pages= 1292–303 |year= 2003 |pmid= 12556489 |doi=
*cite journal | author=Hung WJ, Roberson RS, Taft J, Wu DY |title=Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. |journal=Mol. Cell. Biol. |volume=23 |issue= 10 |pages= 3477–86 |year= 2003 |pmid= 12724406 |doi=
*cite journal | author=Hollander MC, Poola-Kella S, Fornace AJ |title=Gadd34 functional domains involved in growth suppression and apoptosis. |journal=Oncogene |volume=22 |issue= 25 |pages= 3827–32 |year= 2003 |pmid= 12813455 |doi= 10.1038/sj.onc.1206567
*cite journal | author=Powolny A, Takahashi K, Hopkins RG, Loo G |title=Induction of GADD gene expression by phenethylisothiocyanate in human colon adenocarcinoma cells. |journal=J. Cell. Biochem. |volume=90 |issue= 6 |pages= 1128–39 |year= 2004 |pmid= 14635187 |doi= 10.1002/jcb.10733
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Shi W, Sun C, He B, "et al." |title=GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. |journal=J. Cell Biol. |volume=164 |issue= 2 |pages= 291–300 |year= 2004 |pmid= 14718519 |doi= 10.1083/jcb.200307151
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104

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