MAPRE1

Microtubule-associated protein, RP/EB family, member 1, also known as MAPRE1, is a human gene.cite web | title = Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22919| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.cite web | title = Entrez Gene: MAPRE1 microtubule-associated protein, RP/EB family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22919| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tirnauer JS, Bierer BE |title=EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. |journal=J. Cell Biol. |volume=149 |issue= 4 |pages= 761–6 |year= 2000 |pmid= 10811817 |doi=
*cite journal | author=Su LK, Burrell M, Hill DE, "et al." |title=APC binds to the novel protein EB1. |journal=Cancer Res. |volume=55 |issue= 14 |pages= 2972–7 |year= 1995 |pmid= 7606712 |doi=
*cite journal | author=Berrueta L, Kraeft SK, Tirnauer JS, "et al." |title=The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10596–601 |year= 1998 |pmid= 9724749 |doi=
*cite journal | author=Morrison EE, Wardleworth BN, Askham JM, "et al." |title=EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. |journal=Oncogene |volume=17 |issue= 26 |pages= 3471–7 |year= 1999 |pmid= 10030671 |doi= 10.1038/sj.onc.1202247
*cite journal | author=Juwana JP, Henderikx P, Mischo A, "et al." |title=EB/RP gene family encodes tubulin binding proteins. |journal=Int. J. Cancer |volume=81 |issue= 2 |pages= 275–84 |year= 1999 |pmid= 10188731 |doi=
*cite journal | author=Berrueta L, Tirnauer JS, Schuyler SC, "et al." |title=The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. |journal=Curr. Biol. |volume=9 |issue= 8 |pages= 425–8 |year= 1999 |pmid= 10226031 |doi=
*cite journal | author=Nakagawa H, Koyama K, Murata Y, "et al." |title=EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. |journal=Oncogene |volume=19 |issue= 2 |pages= 210–6 |year= 2000 |pmid= 10644998 |doi= 10.1038/sj.onc.1203308
*cite journal | author=Askham JM, Moncur P, Markham AF, Morrison EE |title=Regulation and function of the interaction between the APC tumour suppressor protein and EB1. |journal=Oncogene |volume=19 |issue= 15 |pages= 1950–8 |year= 2000 |pmid= 10773885 |doi= 10.1038/sj.onc.1203498
*cite journal | author=Mimori-Kiyosue Y, Shiina N, Tsukita S |title=The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. |journal=Curr. Biol. |volume=10 |issue= 14 |pages= 865–8 |year= 2000 |pmid= 10899006 |doi=
*cite journal | author=Nakamura M, Zhou XZ, Lu KP |title=Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. |journal=Curr. Biol. |volume=11 |issue= 13 |pages= 1062–7 |year= 2001 |pmid= 11470413 |doi=
*cite journal | author=Zhou XZ, Lu KP |title=The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. |journal=Cell |volume=107 |issue= 3 |pages= 347–59 |year= 2001 |pmid= 11701125 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Nakamura M, Zhou XZ, Kishi S, Lu KP |title=Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 193–8 |year= 2002 |pmid= 11943150 |doi=
*cite journal | author=Askham JM, Vaughan KT, Goodson HV, Morrison EE |title=Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3627–45 |year= 2003 |pmid= 12388762 |doi= 10.1091/mbc.E02-01-0061
*cite journal | author=Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ |title=EB1 targets to kinetochores with attached, polymerizing microtubules. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4308–16 |year= 2003 |pmid= 12475954 |doi= 10.1091/mbc.E02-04-0236
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ligon LA, Shelly SS, Tokito M, Holzbaur EL |title=The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization. |journal=Mol. Biol. Cell |volume=14 |issue= 4 |pages= 1405–17 |year= 2003 |pmid= 12686597 |doi= 10.1091/mbc.E02-03-0155
*cite journal | author=Hayashi I, Ikura M |title=Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36430–4 |year= 2003 |pmid= 12857735 |doi= 10.1074/jbc.M305773200
*cite journal | author=Bu W, Su LK |title=Characterization of functional domains of human EB1 family proteins. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49721–31 |year= 2004 |pmid= 14514668 |doi= 10.1074/jbc.M306194200

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