EIF6

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene.

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.cite web | title = Entrez Gene: ITGB4BP integrin beta 4 binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3692| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Biffo S, Sanvito F, Costa S, "et al." |title=Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30314–21 |year= 1997 |pmid= 9374518 |doi=10.1074/jbc.272.48.30314
*cite journal | author=Si K, Chaudhuri J, Chevesich J, Maitra U |title=Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14285–90 |year= 1998 |pmid= 9405604 |doi=10.1073/pnas.94.26.14285
*cite journal | author=Mao M, Fu G, Wu JS, "et al." |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175–80 |year= 1998 |pmid= 9653160 |doi=10.1073/pnas.95.14.8175
*cite journal | author=Sanvito F, Arrigo G, Zuffardi O, "et al." |title=Localization of p27 beta4 binding protein gene (ITGB4BP) to human chromosome region 20q11.2 |journal= Genomics|volume=52 |issue= 1 |pages= 111–2 |year= 1998|pmid= 9740680 |doi= 10.1006/geno.1998.5403
*cite journal | author=Sanvito F, Piatti S, Villa A, "et al." |title=The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly. |journal=J. Cell Biol. |volume=144 |issue= 5 |pages= 823–37 |year= 1999 |pmid= 10085284 |doi=10.1083/jcb.144.5.823
*cite journal | author=Sanvito F, Arrigo G, Zuffardi O, "et al." |title=Localization of p27 beta 4 binding protein gene (ITGB4BP) to human chromosome region 20q11.2. |journal=Genomics |volume=52 |issue= 1 |pages= 111–2 |year= 1999 |pmid= 10348637 |doi=10.1006/geno.1998.5403
*cite journal | author=Wixler V, Geerts D, Laplantine E, "et al." |title=The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33669–78 |year= 2000 |pmid= 10906324 |doi= 10.1074/jbc.M002519200
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200
*cite journal | author=Donadini A, Giodini A, Sanvito F, "et al." |title=The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo. |journal=Gene |volume=266 |issue= 1-2 |pages= 35–43 |year= 2001 |pmid= 11290417 |doi=10.1016/S0378-1119(01)00370-5
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Basu U, Si K, Deng H, Maitra U |title=Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p: evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6187–99 |year= 2003 |pmid= 12917340 |doi=10.1128/MCB.23.17.6187-6199.2003
*cite journal | author=Ceci M, Gaviraghi C, Gorrini C, "et al." |title=Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly. |journal=Nature |volume=426 |issue= 6966 |pages= 579–84 |year= 2003 |pmid= 14654845 |doi= 10.1038/nature02160
*cite journal | author=Rosso P, Cortesina G, Sanvito F, "et al." |title=Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases. |journal=Head Neck |volume=26 |issue= 5 |pages= 408–17 |year= 2004 |pmid= 15122657 |doi= 10.1002/hed.10401
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029

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