INSIG1

Insulin induced gene 1, also known as INSIG1, is a human gene.cite web | title = Entrez Gene: INSIG1 insulin induced gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3638| accessdate = ]

PBB_Summary
section_title =
summary_text = Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: INSIG1 insulin induced gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3638| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Peng Y, Schwarz EJ, Lazar MA, "et al." |title=Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. |journal=Genomics |volume=43 |issue= 3 |pages= 278–84 |year= 1997 |pmid= 9268630 |doi= 10.1006/geno.1997.4821
*cite journal | author=Kaneda A, Kaminishi M, Nakanishi Y, "et al." |title=Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers. |journal=Int. J. Cancer |volume=100 |issue= 1 |pages= 57–62 |year= 2002 |pmid= 12115587 |doi= 10.1002/ijc.10464
*cite journal | author=Yang T, Espenshade PJ, Wright ME, "et al." |title=Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. |journal=Cell |volume=110 |issue= 4 |pages= 489–500 |year= 2002 |pmid= 12202038 |doi=
*cite journal | author=Yabe D, Brown MS, Goldstein JL |title=Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12753–8 |year= 2002 |pmid= 12242332 |doi= 10.1073/pnas.162488899
*cite journal | author=Janowski BA |title=The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12675–80 |year= 2002 |pmid= 12242342 |doi= 10.1073/pnas.202471599
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yabe D, Xia ZP, Adams CM, Rawson RB |title=Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16672–7 |year= 2003 |pmid= 12482938 |doi= 10.1073/pnas.262669399
*cite journal | author=Sever N, Yang T, Brown MS, "et al." |title=Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 25–33 |year= 2003 |pmid= 12535518 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB |title=Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35837–43 |year= 2003 |pmid= 12842885 |doi= 10.1074/jbc.M306476200
*cite journal | author=Li J, Takaishi K, Cook W, "et al." |title=Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 16 |pages= 9476–81 |year= 2003 |pmid= 12869692 |doi= 10.1073/pnas.1133426100
*cite journal | author=Adams CM, Goldstein JL, Brown MS |title=Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 19 |pages= 10647–52 |year= 2003 |pmid= 12963821 |doi= 10.1073/pnas.1534833100
*cite journal | author=Feramisco JD, Goldstein JL, Brown MS |title=Membrane topology of human insig-1, a protein regulator of lipid synthesis. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 8487–96 |year= 2004 |pmid= 14660594 |doi= 10.1074/jbc.M312623200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Engelking LJ, Kuriyama H, Hammer RE, "et al." |title=Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. |journal=J. Clin. Invest. |volume=113 |issue= 8 |pages= 1168–75 |year= 2004 |pmid= 15085196 |doi= 10.1172/JCI200420978
*cite journal | author=Sever N, Lee PC, Song BL, "et al." |title=Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 43136–47 |year= 2004 |pmid= 15247248 |doi= 10.1074/jbc.M406406200
*cite journal | author=Lee JN, Ye J |title=Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 45257–65 |year= 2004 |pmid= 15304479 |doi= 10.1074/jbc.M408235200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Suchanek M, Radzikowska A, Thiele C |title=Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells. |journal=Nat. Methods |volume=2 |issue= 4 |pages= 261–7 |year= 2005 |pmid= 15782218 |doi= 10.1038/nmeth752
*cite journal | author=Sun LP, Li L, Goldstein JL, Brown MS |title=Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. |journal=J. Biol. Chem. |volume=280 |issue= 28 |pages= 26483–90 |year= 2005 |pmid= 15899885 |doi= 10.1074/jbc.M504041200

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