INSIG2

Insulin induced gene 2, also known as INSIG2, is a human gene.cite web | title = Entrez Gene: INSIG2 insulin induced gene 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51141| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.cite web | title = Entrez Gene: INSIG2 insulin induced gene 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51141| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yabe D, Brown MS, Goldstein JL |title=Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12753–8 |year= 2002 |pmid= 12242332 |doi= 10.1073/pnas.162488899
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yabe D, Xia ZP, Adams CM, Rawson RB |title=Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16672–7 |year= 2003 |pmid= 12482938 |doi= 10.1073/pnas.262669399
*cite journal | author=Yabe D, Komuro R, Liang G, "et al." |title=Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 6 |pages= 3155–60 |year= 2003 |pmid= 12624180 |doi= 10.1073/pnas.0130116100
*cite journal | author=Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB |title=Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35837–43 |year= 2003 |pmid= 12842885 |doi= 10.1074/jbc.M306476200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lee JN, Gong Y, Zhang X, Ye J |title=Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 13 |pages= 4958–63 |year= 2006 |pmid= 16549805 |doi= 10.1073/pnas.0600422103
*cite journal | author=Gong Y, Lee JN, Brown MS, "et al." |title=Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 16 |pages= 6154–9 |year= 2006 |pmid= 16606821 |doi= 10.1073/pnas.0601923103
*cite journal | author=Radhakrishnan A, Ikeda Y, Kwon HJ, "et al." |title=Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 16 |pages= 6511–8 |year= 2007 |pmid= 17428920 |doi= 10.1073/pnas.0700899104
*cite journal | author=Lyon HN, Emilsson V, Hinney A, "et al." |title=The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. |journal=PLoS Genet. |volume=3 |issue= 4 |pages= e61 |year= 2007 |pmid= 17465681 |doi= 10.1371/journal.pgen.0030061
*cite journal | author=Kumar J, Sunkishala RR, Karthikeyan G, Sengupta S |title=The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population. |journal=Clin. Genet. |volume=71 |issue= 5 |pages= 415–8 |year= 2007 |pmid= 17489846 |doi= 10.1111/j.1399-0004.2007.00795.x

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