HIST2H4A

Histone cluster 2, H4a, also known as HIST2H4A, is a human gene.cite web | title = Entrez Gene: HIST2H4A histone cluster 2, H4a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8370| accessdate = ]

PBB_Summary
section_title =
summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.cite web | title = Entrez Gene: HIST2H4A histone cluster 2, H4a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8370| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pauli U, Chrysogelos S, Stein G, "et al." |title=Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. |journal=Science |volume=236 |issue= 4806 |pages= 1308–11 |year= 1987 |pmid= 3035717 |doi=
*cite journal | author=Sierra F, Stein G, Stein J |title=Structure and in vitro transcription of a human H4 histone gene. |journal=Nucleic Acids Res. |volume=11 |issue= 20 |pages= 7069–86 |year= 1983 |pmid= 6314274 |doi=
*cite journal | author=Green L, Van Antwerpen R, Stein J, "et al." |title=A major human histone gene cluster on the long arm of chromosome 1. |journal=Science |volume=226 |issue= 4676 |pages= 838–40 |year= 1984 |pmid= 6494913 |doi=
*cite journal | author=Pelicci G, Lanfrancone L, Salcini AE, "et al." |title=Constitutive phosphorylation of Shc proteins in human tumors. |journal=Oncogene |volume=11 |issue= 5 |pages= 899–907 |year= 1995 |pmid= 7675449 |doi=
*cite journal | author=Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M |title=Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. |journal=Biochim. Biophys. Acta |volume=1296 |issue= 2 |pages= 219–27 |year= 1996 |pmid= 8814229 |doi=
*cite journal | author=Rodriguez P, Munroe D, Prawitt D, "et al." |title=Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. |journal=Genomics |volume=44 |issue= 3 |pages= 253–65 |year= 1997 |pmid= 9325046 |doi= 10.1006/geno.1997.4868
*cite journal | author=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=
*cite journal | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi=
*cite journal | author=Kimura A, Horikoshi M |title=Tip60 acetylates six lysines of a specific class in core histones in vitro. |journal=Genes Cells |volume=3 |issue= 12 |pages= 789–800 |year= 1999 |pmid= 10096020 |doi=
*cite journal | author=Deng L, de la Fuente C, Fu P, "et al." |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593
*cite journal | author=Seo SB, McNamara P, Heo S, "et al." |title=Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. |journal=Cell |volume=104 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11163245 |doi=
*cite journal | author=Deng L, Wang D, de la Fuente C, "et al." |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Weinmann AS, Yan PS, Oberley MJ, "et al." |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235–44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102
*cite journal | author=Marzluff WF, Gongidi P, Woods KR, "et al." |title=The human and mouse replication-dependent histone genes. |journal=Genomics |volume=80 |issue= 5 |pages= 487–98 |year= 2003 |pmid= 12408966 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hovhannisyan H, Cho B, Mitra P, "et al." |title=Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. |journal=Mol. Cell. Biol. |volume=23 |issue= 4 |pages= 1460–9 |year= 2003 |pmid= 12556504 |doi=
*cite journal | author=Yoon HG, Chan DW, Huang ZQ, "et al." |title=Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1336–46 |year= 2003 |pmid= 12628926 |doi= 10.1093/emboj/cdg120
*cite journal | author=Pivot-Pajot C, Caron C, Govin J, "et al." |title=Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. |journal=Mol. Cell. Biol. |volume=23 |issue= 15 |pages= 5354–65 |year= 2003 |pmid= 12861021 |doi=
*cite journal | author=Coleman MA, Miller KA, Beernink PT, "et al." |title=Identification of chromatin-related protein interactions using protein microarrays. |journal=Proteomics |volume=3 |issue= 11 |pages= 2101–7 |year= 2004 |pmid= 14595808 |doi= 10.1002/pmic.200300593

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