APLP1

Amyloid beta (A4) precursor-like protein 1, also known as APLP1, is a human gene.cite web | title = Entrez Gene: APLP1 amyloid beta (A4) precursor-like protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=333| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: APLP1 amyloid beta (A4) precursor-like protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=333| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bayer TA, Cappai R, Masters CL, "et al." |title=It all sticks together--the APP-related family of proteins and Alzheimer's disease. |journal=Mol. Psychiatry |volume=4 |issue= 6 |pages= 524–8 |year= 2000 |pmid= 10578233 |doi=
*cite journal | author=Kim TW, Wu K, Xu JL, "et al." |title=Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. |journal=Brain Res. Mol. Brain Res. |volume=32 |issue= 1 |pages= 36–44 |year= 1996 |pmid= 7494461 |doi=
*cite journal | author=Bush AI, Pettingell WH, de Paradis M, "et al." |title=The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. |journal=J. Biol. Chem. |volume=269 |issue= 43 |pages= 26618–21 |year= 1994 |pmid= 7929392 |doi=
*cite journal | author=Wasco W, Brook JD, Tanzi RE |title=The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. |journal=Genomics |volume=15 |issue= 1 |pages= 237–9 |year= 1993 |pmid= 8432545 |doi= 10.1006/geno.1993.1047
*cite journal | author=Bressler SL, Gray MD, Sopher BL, "et al." |title=cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. |journal=Hum. Mol. Genet. |volume=5 |issue= 10 |pages= 1589–98 |year= 1997 |pmid= 8894693 |doi=
*cite journal | author=Paliga K, Peraus G, Kreger S, "et al." |title=Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. |journal=Eur. J. Biochem. |volume=250 |issue= 2 |pages= 354–63 |year= 1998 |pmid= 9428684 |doi=
*cite journal | author=Lenkkeri U, Kestilä M, Lamerdin J, "et al." |title=Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. |journal=Hum. Genet. |volume=102 |issue= 2 |pages= 192–6 |year= 1998 |pmid= 9521588 |doi=
*cite journal | author=McNamara MJ, Ruff CT, Wasco W, "et al." |title=Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. |journal=Brain Res. |volume=804 |issue= 1 |pages= 45–51 |year= 1998 |pmid= 9729270 |doi=
*cite journal | author=Tomita S, Ozaki T, Taru H, "et al." |title=Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2243–54 |year= 1999 |pmid= 9890987 |doi=
*cite journal | author=Homayouni R, Rice DS, Sheldon M, Curran T |title=Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. |journal=J. Neurosci. |volume=19 |issue= 17 |pages= 7507–15 |year= 1999 |pmid= 10460257 |doi=
*cite journal | author=Simons A, Ruppert T, Schmidt C, "et al." |title=Evidence for a copper-binding superfamily of the amyloid precursor protein. |journal=Biochemistry |volume=41 |issue= 30 |pages= 9310–20 |year= 2002 |pmid= 12135352 |doi=
*cite journal | author=Scheinfeld MH, Ghersi E, Laky K, "et al." |title=Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44195–201 |year= 2003 |pmid= 12228233 |doi= 10.1074/jbc.M208110200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Walsh DM, Fadeeva JV, LaVoie MJ, "et al." |title=gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. |journal=Biochemistry |volume=42 |issue= 22 |pages= 6664–73 |year= 2003 |pmid= 12779321 |doi= 10.1021/bi027375c
*cite journal | author=Yamakami M, Yoshimori T, Yokosawa H |title=Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52865–72 |year= 2004 |pmid= 14563850 |doi= 10.1074/jbc.M306740200
*cite journal | author=Adlerz L, Beckman M, Holback S, "et al." |title=Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction. |journal=Brain Res. Mol. Brain Res. |volume=119 |issue= 1 |pages= 62–72 |year= 2004 |pmid= 14597230 |doi=
*cite journal | author=Li Q, Südhof TC |title=Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10542–50 |year= 2004 |pmid= 14699153 |doi= 10.1074/jbc.M310001200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Eggert S, Paliga K, Soba P, "et al." |title=The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18146–56 |year= 2004 |pmid= 14970212 |doi= 10.1074/jbc.M311601200

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