G3BP1

GTPase activating protein (SH3 domain) binding protein 1, also known as G3BP1, is a human gene.cite web | title = Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10146| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.cite web | title = Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10146| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Irvine K, Stirling R, Hume D, Kennedy D |title=Rasputin, more promiscuous than ever: a review of G3BP. |journal=Int. J. Dev. Biol. |volume=48 |issue= 10 |pages= 1065–77 |year= 2005 |pmid= 15602692 |doi= 10.1387/ijdb.041893ki
*cite journal | author=Onno M, Nakamura T, Hillova J, Hill M |title=Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes. |journal=Oncogene |volume=7 |issue= 12 |pages= 2519–23 |year= 1993 |pmid= 1461655 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Parker F, Maurier F, Delumeau I, "et al." |title=A Ras-GTPase-activating protein SH3-domain-binding protein. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 2561–9 |year= 1996 |pmid= 8649363 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Gallouzi IE, Parker F, Chebli K, "et al." |title=A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 3956–65 |year= 1998 |pmid= 9632780 |doi=
*cite journal | author=Costa M, Ochem A, Staub A, Falaschi A |title=Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. |journal=Nucleic Acids Res. |volume=27 |issue= 3 |pages= 817–21 |year= 1999 |pmid= 9889278 |doi=
*cite journal | author=Kociok N, Esser P, Unfried K, "et al." |title=Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells. |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 194–201 |year= 1999 |pmid= 10404389 |doi=
*cite journal | author=Soncini C, Berdo I, Draetta G |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. |journal=Oncogene |volume=20 |issue= 29 |pages= 3869–79 |year= 2001 |pmid= 11439350 |doi= 10.1038/sj.onc.1204553
*cite journal | author=Tourrière H, Gallouzi IE, Chebli K, "et al." |title=RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7747–60 |year= 2001 |pmid= 11604510 |doi= 10.1128/MCB.21.22.7747-7760.2001
*cite journal | author=Barnes CJ, Li F, Mandal M, "et al." |title=Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors. |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1251–5 |year= 2002 |pmid= 11888885 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tourrière H, Chebli K, Zekri L, "et al." |title=The RasGAP-associated endoribonuclease G3BP assembles stress granules. |journal=J. Cell Biol. |volume=160 |issue= 6 |pages= 823–31 |year= 2003 |pmid= 12642610 |doi= 10.1083/jcb.200212128
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Katsafanas GC, Moss B |title=Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer. |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52210–7 |year= 2005 |pmid= 15471883 |doi= 10.1074/jbc.M411033200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715

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