ADARB1

Adenosine deaminase, RNA-specific, B1 (RED1 homolog rat), also known as ADARB1, is a human gene.cite web | title = Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=104| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.cite web | title = Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=104| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Valenzuela A, Blanco J, Callebaut C, "et al." |title=HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26. |journal=Adv. Exp. Med. Biol. |volume=421 |issue= |pages= 185–92 |year= 1997 |pmid= 9330696 |doi=
*cite journal | author=Keegan LP, Leroy A, Sproul D, O'Connell MA |title=Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes. |journal=Genome Biol. |volume=5 |issue= 2 |pages= 209 |year= 2005 |pmid= 14759252 |doi= 10.1186/gb-2004-5-2-209
*cite journal | author=Melcher T, Maas S, Herb A, "et al." |title=A mammalian RNA editing enzyme. |journal=Nature |volume=379 |issue= 6564 |pages= 460–4 |year= 1996 |pmid= 8559253 |doi= 10.1038/379460a0
*cite journal | author=O'Connell MA, Gerber A, Keller W |title=Purification of human double-stranded RNA-specific editase 1 (hRED1) involved in editing of brain glutamate receptor B pre-mRNA. |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 473–8 |year= 1997 |pmid= 8995285 |doi=
*cite journal | author=Valenzuela A, Blanco J, Callebaut C, "et al." |title=Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles. |journal=J. Immunol. |volume=158 |issue= 8 |pages= 3721–9 |year= 1997 |pmid= 9103436 |doi=
*cite journal | author=Lai F, Chen CX, Carter KC, Nishikura K |title=Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases. |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2413–24 |year= 1997 |pmid= 9111310 |doi=
*cite journal | author=Yang JH, Sklar P, Axel R, Maniatis T |title=Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4354–9 |year= 1997 |pmid= 9113993 |doi=
*cite journal | author=Mittaz L, Scott HS, Rossier C, "et al." |title=Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3. |journal=Genomics |volume=41 |issue= 2 |pages= 210–7 |year= 1997 |pmid= 9143496 |doi= 10.1006/geno.1997.4655
*cite journal | author=Gerber A, O'Connell MA, Keller W |title=Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette. |journal=RNA |volume=3 |issue= 5 |pages= 453–63 |year= 1997 |pmid= 9149227 |doi=
*cite journal | author=Villard L, Tassone F, Haymowicz M, "et al." |title=Map location, genomic organization and expression patterns of the human RED1 RNA editase. |journal=Somat. Cell Mol. Genet. |volume=23 |issue= 2 |pages= 135–45 |year= 1997 |pmid= 9330641 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Blanco J, Valenzuela A, Herrera C, "et al." |title=The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression. |journal=FEBS Lett. |volume=477 |issue= 1-2 |pages= 123–8 |year= 2000 |pmid= 10899322 |doi=
*cite journal | author=Herrera C, Morimoto C, Blanco J, "et al." |title=Comodulation of CXCR4 and CD26 in human lymphocytes. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19532–9 |year= 2001 |pmid= 11278278 |doi= 10.1074/jbc.M004586200
*cite journal | author=Maas S, Patt S, Schrey M, Rich A |title=Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 25 |pages= 14687–92 |year= 2002 |pmid= 11717408 |doi= 10.1073/pnas.251531398
*cite journal | author=Jayan GC, Casey JL |title=Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2. |journal=J. Virol. |volume=76 |issue= 8 |pages= 3819–27 |year= 2002 |pmid= 11907222 |doi=
*cite journal | author=Jaikaran DC, Collins CH, MacMillan AM |title=Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37624–9 |year= 2002 |pmid= 12163487 |doi= 10.1074/jbc.M204126200
*cite journal | author=Jayan GC, Casey JL |title=Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression. |journal=J. Virol. |volume=76 |issue= 23 |pages= 12399–404 |year= 2002 |pmid= 12414985 |doi=
*cite journal | author=Slavov D, Gardiner K |title=Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns. |journal=Gene |volume=299 |issue= 1-2 |pages= 83–94 |year= 2003 |pmid= 12459255 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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