HIST1H4I

Histone cluster 1, H4i, also known as HIST1H4I, is a human gene.cite web | title = Entrez Gene: HIST1H4I histone cluster 1, H4i| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8294| accessdate = ]

PBB_Summary
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summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.cite web | title = Entrez Gene: HIST1H4I histone cluster 1, H4i| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8294| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Albig W, Kardalinou E, Drabent B, "et al." |title=Isolation and characterization of two human H1 histone genes within clusters of core histone genes. |journal=Genomics |volume=10 |issue= 4 |pages= 940–8 |year= 1991 |pmid= 1916825 |doi=
*cite journal | author=Turner BM, O'Neill LP, Allan IM |title=Histone H4 acetylation in human cells. Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies. |journal=FEBS Lett. |volume=253 |issue= 1-2 |pages= 141–5 |year= 1989 |pmid= 2474456 |doi=
*cite journal | author=Pauli U, Chrysogelos S, Stein G, "et al." |title=Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. |journal=Science |volume=236 |issue= 4806 |pages= 1308–11 |year= 1987 |pmid= 3035717 |doi=
*cite journal | author=Ebralidse KK, Grachev SA, Mirzabekov AD |title=A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA. |journal=Nature |volume=331 |issue= 6154 |pages= 365–7 |year= 1988 |pmid= 3340182 |doi= 10.1038/331365a0
*cite journal | author=Sierra F, Stein G, Stein J |title=Structure and in vitro transcription of a human H4 histone gene. |journal=Nucleic Acids Res. |volume=11 |issue= 20 |pages= 7069–86 |year= 1983 |pmid= 6314274 |doi=
*cite journal | author=Drabent B, Kardalinou E, Bode C, Doenecke D |title=Association of histone H4 genes with the mammalian testis-specific H1t histone gene. |journal=DNA Cell Biol. |volume=14 |issue= 7 |pages= 591–7 |year= 1995 |pmid= 7626218 |doi=
*cite journal | author=Akasaka T, Miura I, Takahashi N, "et al." |title=A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene. |journal=Cancer Res. |volume=57 |issue= 1 |pages= 7–12 |year= 1997 |pmid= 8988030 |doi=
*cite journal | author=Albig W, Meergans T, Doenecke D |title=Characterization of the H1.5 gene completes the set of human H1 subtype genes. |journal=Gene |volume=184 |issue= 2 |pages= 141–8 |year= 1997 |pmid= 9031620 |doi=
*cite journal | author=Albig W, Kioschis P, Poustka A, "et al." |title=Human histone gene organization: nonregular arrangement within a large cluster. |journal=Genomics |volume=40 |issue= 2 |pages= 314–22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592
*cite journal | author=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=
*cite journal | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi=
*cite journal | author=Albig W, Trappe R, Kardalinou E, "et al." |title=The human H2A and H2B histone gene complement. |journal=Biol. Chem. |volume=380 |issue= 1 |pages= 7–18 |year= 1999 |pmid= 10064132 |doi=
*cite journal | author=Ahn J, Gruen JR |title=The genomic organization of the histone clusters on human 6p21.3. |journal=Mamm. Genome |volume=10 |issue= 7 |pages= 768–70 |year= 1999 |pmid= 10384058 |doi=
*cite journal | author=Deng L, de la Fuente C, Fu P, "et al." |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593
*cite journal | author=Deng L, Wang D, de la Fuente C, "et al." |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129
*cite journal | author=Marzluff WF, Gongidi P, Woods KR, "et al." |title=The human and mouse replication-dependent histone genes. |journal=Genomics |volume=80 |issue= 5 |pages= 487–98 |year= 2003 |pmid= 12408966 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086

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