XDH (gene)

Xanthine dehydrogenase, also known as XDH, is a human gene.cite web | title = Entrez Gene: XDH xanthine dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7498| accessdate = ]

PBB_Summary
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summary_text = Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.cite web | title = Entrez Gene: XDH xanthine dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7498| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Meneshian A, Bulkley GB |title=The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction. |journal=Microcirculation (New York, N.Y. : 1994) |volume=9 |issue= 3 |pages= 161–75 |year= 2002 |pmid= 12080414 |doi= 10.1038/sj.mn.7800136
*cite journal | author=Xu P, Huecksteadt TP, Harrison R, Hoidal JR |title=Molecular cloning, tissue expression of human xanthine dehydrogenase. |journal=Biochem. Biophys. Res. Commun. |volume=215 |issue= 1 |pages= 429 |year= 1995 |pmid= 7575623 |doi=
*cite journal | author=Xu P, Zhu XL, Huecksteadt TP, "et al." |title=Assignment of human xanthine dehydrogenase gene to chromosome 2p22. |journal=Genomics |volume=23 |issue= 1 |pages= 289–91 |year= 1995 |pmid= 7829092 |doi= 10.1006/geno.1994.1498
*cite journal | author=Minoshima S, Wang Y, Ichida K, "et al." |title=Mapping of the gene for human xanthine dehydrogenase (oxidase) (XDH) to band p23 of chromosome 2. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 52–3 |year= 1994 |pmid= 7956358 |doi=
*cite journal | author=Rytkönen EM, Halila R, Laan M, "et al." |title=The human gene for xanthine dehydrogenase (XDH) is localized on chromosome band 2q22. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 61–3 |year= 1994 |pmid= 7956361 |doi=
*cite journal | author=Xu P, Huecksteadt TP, Harrison R, Hoidal JR |title=Molecular cloning, tissue expression of human xanthine dehydrogenase. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 2 |pages= 998–1004 |year= 1994 |pmid= 8135849 |doi= 10.1006/bbrc.1994.1328
*cite journal | author=Ichida K, Amaya Y, Noda K, "et al." |title=Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene. |journal=Gene |volume=133 |issue= 2 |pages= 279–84 |year= 1993 |pmid= 8224915 |doi=
*cite journal | author=Satoh A, Sasago S, Takahashi S, Kato N |title=Regulation of xanthine dehydrogenase in rat liver in response to peroxisome proliferators. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 751–7 |year= 1993 |pmid= 8373410 |doi= 10.1006/bbrc.1993.2109
*cite journal | author=Xu P, Huecksteadt TP, Hoidal JR |title=Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). |journal=Genomics |volume=34 |issue= 2 |pages= 173–80 |year= 1997 |pmid= 8661045 |doi= 10.1006/geno.1996.0262
*cite journal | author=Saksela M, Raivio KO |title=Cloning and expression in vitro of human xanthine dehydrogenase/oxidase. |journal=Biochem. J. |volume=315 ( Pt 1) |issue= |pages= 235–9 |year= 1996 |pmid= 8670112 |doi=
*cite journal | author=Many A, Westerhausen-Larson A, Kanbour-Shakir A, Roberts JM |title=Xanthine oxidase/dehydrogenase is present in human placenta. |journal=Placenta |volume=17 |issue= 5-6 |pages= 361–5 |year= 1996 |pmid= 8829220 |doi=
*cite journal | author=Hellsten Y, Frandsen U, Orthenblad N, "et al." |title=Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation. |journal=J. Physiol. (Lond.) |volume=498 ( Pt 1) |issue= |pages= 239–48 |year= 1997 |pmid= 9023782 |doi=
*cite journal | author=Ichida K, Amaya Y, Kamatani N, "et al." |title=Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria. |journal=J. Clin. Invest. |volume=99 |issue= 10 |pages= 2391–7 |year= 1997 |pmid= 9153281 |doi=
*cite journal | author=Rouquette M, Stevens C, Blake DR, "et al." |title=Expression of xanthine oxidase activity in human endothelial cells as a function of cell density. |journal=Biochem. Soc. Trans. |volume=25 |issue= 3 |pages= 532S |year= 1998 |pmid= 9388748 |doi=
*cite journal | author=Newaz MA, Adeeb NN |title=Detection of xanthine oxidase in human plasma. |journal=Med. J. Malaysia |volume=53 |issue= 1 |pages= 70–5 |year= 2000 |pmid= 10968141 |doi=
*cite journal | author=Martelin E, Palvimo JJ, Lapatto R, Raivio KO |title=Nuclear factor Y activates the human xanthine oxidoreductase gene promoter. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 84–8 |year= 2000 |pmid= 11034305 |doi=
*cite journal | author=Stiborová M, Frei E, Sopko B, "et al." |title=Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy. |journal=Carcinogenesis |volume=23 |issue= 4 |pages= 617–25 |year= 2002 |pmid= 11960915 |doi=
*cite journal | author=Frederiks WM, Vreeling-Sindelárová H |title=Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells. |journal=Acta Histochem. |volume=104 |issue= 1 |pages= 29–37 |year= 2002 |pmid= 11993848 |doi=
*cite journal | author=Cejková J, Ardan T, Filipec M, Midelfart A |title=Xanthine oxidoreductase and xanthine oxidase in human cornea. |journal=Histol. Histopathol. |volume=17 |issue= 3 |pages= 755–60 |year= 2003 |pmid= 12168784 |doi=

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