SUMO3

SUMO3

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae), also known as SUMO3, is a human gene.cite web | title = Entrez Gene: SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6612| accessdate = ]

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summary_text = SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002). [supplied by OMIM] cite web | title = Entrez Gene: SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6612| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Lapenta V, Chiurazzi P, van der Spek P, "et al." |title=SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. |journal=Genomics |volume=40 |issue= 2 |pages= 362–6 |year= 1997 |pmid= 9119407 |doi= 10.1006/geno.1996.4556
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Saitoh H, Hinchey J |title=Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6252–8 |year= 2000 |pmid= 10692421 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Tatham MH, Jaffray E, Vaughan OA, "et al." |title=Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35368–74 |year= 2001 |pmid= 11451954 |doi= 10.1074/jbc.M104214200
*cite journal | author=Lin J, Johannsen E, Robertson E, Kieff E |title=Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2. |journal=J. Virol. |volume=76 |issue= 1 |pages= 232–42 |year= 2002 |pmid= 11739688 |doi=
*cite journal | author=Kadoya T, Yamamoto H, Suzuki T, "et al." |title=Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3803–19 |year= 2002 |pmid= 11997515 |doi=
*cite journal | author=Su HL, Li SS |title=Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. |journal=Gene |volume=296 |issue= 1-2 |pages= 65–73 |year= 2003 |pmid= 12383504 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Subramanian L, Benson MD, Iñiguez-Lluhí JA |title=A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9134–41 |year= 2003 |pmid= 12511558 |doi= 10.1074/jbc.M210440200
*cite journal | author=Eaton EM, Sealy L |title=Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33416–21 |year= 2003 |pmid= 12810706 |doi= 10.1074/jbc.M305680200
*cite journal | author=Tatham MH, Kim S, Yu B, "et al." |title=Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. |journal=Biochemistry |volume=42 |issue= 33 |pages= 9959–69 |year= 2003 |pmid= 12924945 |doi= 10.1021/bi0345283
*cite journal | author=Dobreva G, Dambacher J, Grosschedl R |title=SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. |journal=Genes Dev. |volume=17 |issue= 24 |pages= 3048–61 |year= 2004 |pmid= 14701874 |doi= 10.1101/gad.1153003
*cite journal | author=Reverter D, Lima CD |title=A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. |journal=Structure |volume=12 |issue= 8 |pages= 1519–31 |year= 2005 |pmid= 15296745 |doi= 10.1016/j.str.2004.05.023
*cite journal | author=Ayaydin F, Dasso M |title=Distinct in vivo dynamics of vertebrate SUMO paralogues. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5208–18 |year= 2005 |pmid= 15456902 |doi= 10.1091/mbc.E04-07-0589
*cite journal | author=Xu Z, Au SW |title=Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. |journal=Biochem. J. |volume=386 |issue= Pt 2 |pages= 325–30 |year= 2005 |pmid= 15487983 |doi= 10.1042/BJ20041210
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ding H, Xu Y, Chen Q, "et al." |title=Solution structure of human SUMO-3 C47S and its binding surface for Ubc9. |journal=Biochemistry |volume=44 |issue= 8 |pages= 2790–9 |year= 2005 |pmid= 15723523 |doi= 10.1021/bi0477586
*cite journal | author=Bossis G, Malnou CE, Farras R, "et al." |title=Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. |journal=Mol. Cell. Biol. |volume=25 |issue= 16 |pages= 6964–79 |year= 2005 |pmid= 16055710 |doi= 10.1128/MCB.25.16.6964-6979.2005

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