AMY2A

Amylase, alpha 2A; pancreatic, also known as AMY2A, is a human gene.cite web | title = Entrez Gene: AMY2A amylase, alpha 2A; pancreatic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=279| accessdate = ]

PBB_Summary
section_title =
summary_text = Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.cite web | title = Entrez Gene: AMY2A amylase, alpha 2A; pancreatic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=279| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kaczmarek MJ, Rosenmund H |title=The action of human pancreatic and salivary isoamylases on starch and glycogen. |journal=Clin. Chim. Acta |volume=79 |issue= 1 |pages= 69–73 |year= 1977 |pmid= 890964 |doi=
*cite journal | author=Jacob M, Lainé J, LeBel D |title=Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase. |journal=Biochem. Cell Biol. |volume=70 |issue= 10-11 |pages= 1105–14 |year= 1993 |pmid= 1284286 |doi=
*cite journal | author=Groot PC, Mager WH, Henriquez NV, "et al." |title=Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers. |journal=Genomics |volume=8 |issue= 1 |pages= 97–105 |year= 1991 |pmid= 2081604 |doi=
*cite journal | author=Nishide T, Nakamura Y, Emi M, "et al." |title=Primary structure of human salivary alpha-amylase gene. |journal=Gene |volume=41 |issue= 2-3 |pages= 299–304 |year= 1986 |pmid= 2423416 |doi=
*cite journal | author=Horii A, Emi M, Tomita N, "et al." |title=Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene. |journal=Gene |volume=60 |issue= 1 |pages= 57–64 |year= 1988 |pmid= 2450054 |doi=
*cite journal | author=Gumucio DL, Wiebauer K, Caldwell RM, "et al." |title=Concerted evolution of human amylase genes. |journal=Mol. Cell. Biol. |volume=8 |issue= 3 |pages= 1197–205 |year= 1988 |pmid= 2452973 |doi=
*cite journal | author=Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH |title=Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene. |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8261–76 |year= 1988 |pmid= 2458567 |doi=
*cite journal | author=Groot PC, Bleeker MJ, Pronk JC, "et al." |title=The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes. |journal=Genomics |volume=5 |issue= 1 |pages= 29–42 |year= 1989 |pmid= 2788608 |doi=
*cite journal | author=Groot PC, Bleeker MJ, Pronk JC, "et al." |title=Human pancreatic amylase is encoded by two different genes. |journal=Nucleic Acids Res. |volume=16 |issue= 10 |pages= 4724 |year= 1988 |pmid= 3260028 |doi=
*cite journal | author=Wise RJ, Karn RC, Larsen SH, "et al." |title=A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A. |journal=Mol. Biol. Med. |volume=2 |issue= 5 |pages= 307–22 |year= 1986 |pmid= 6336237 |doi=
*cite journal | author=Tricoli JV, Shows TB |title=Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1. |journal=Somat. Cell Mol. Genet. |volume=10 |issue= 2 |pages= 205–10 |year= 1984 |pmid= 6608795 |doi=
*cite journal | author=Nishide T, Emi M, Nakamura Y, Matsubara K |title=Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected] |journal=Gene |volume=28 |issue= 2 |pages= 263–70 |year= 1984 |pmid= 6610603 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Qian M, Haser R, Buisson G, "et al." |title=The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution. |journal=Biochemistry |volume=33 |issue= 20 |pages= 6284–94 |year= 1994 |pmid= 8193143 |doi=
*cite journal | author=Brayer GD, Luo Y, Withers SG |title=The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes. |journal=Protein Sci. |volume=4 |issue= 9 |pages= 1730–42 |year= 1996 |pmid= 8528071 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Rydberg EH, Sidhu G, Vo HC, "et al." |title=Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. |journal=Protein Sci. |volume=8 |issue= 3 |pages= 635–43 |year= 1999 |pmid= 10091666 |doi=
*cite journal | author=Brayer GD, Sidhu G, Maurus R, "et al." |title=Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. |journal=Biochemistry |volume=39 |issue= 16 |pages= 4778–91 |year= 2000 |pmid= 10769135 |doi=
*cite journal | author=Aughsteen AA |title=A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas. |journal=Saudi medical journal |volume=22 |issue= 5 |pages= 410–5 |year= 2001 |pmid= 11376382 |doi=
*cite journal | author=Numao S, Maurus R, Sidhu G, "et al." |title=Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase. |journal=Biochemistry |volume=41 |issue= 1 |pages= 215–25 |year= 2002 |pmid= 11772019 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes