SRA1

Steroid receptor RNA activator 1, also known as SRA1, is a human gene.cite web | title = Entrez Gene: SRA1 steroid receptor RNA activator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10011| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is involved in transcriptional coactivation by steroid receptors. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.cite web | title = Entrez Gene: SRA1 steroid receptor RNA activator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10011| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lanz RB, McKenna NJ, Onate SA, "et al." |title=A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. |journal=Cell |volume=97 |issue= 1 |pages= 17–27 |year= 1999 |pmid= 10199399 |doi=
*cite journal | author=Leygue E, Dotzlaw H, Watson PH, Murphy LC |title=Expression of the steroid receptor RNA activator in human breast tumors. |journal=Cancer Res. |volume=59 |issue= 17 |pages= 4190–3 |year= 1999 |pmid= 10485452 |doi=
*cite journal | author=Murphy LC, Simon SL, Parkes A, "et al." |title=Altered expression of estrogen receptor coregulators during human breast tumorigenesis. |journal=Cancer Res. |volume=60 |issue= 22 |pages= 6266–71 |year= 2000 |pmid= 11103781 |doi=
*cite journal | author=Watanabe M, Yanagisawa J, Kitagawa H, "et al." |title=A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1341–52 |year= 2001 |pmid= 11250900 |doi= 10.1093/emboj/20.6.1341
*cite journal | author=Cavarretta IT, Mukopadhyay R, Lonard DM, "et al." |title=Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. |journal=Mol. Endocrinol. |volume=16 |issue= 2 |pages= 253–70 |year= 2002 |pmid= 11818499 |doi=
*cite journal | author=Kucera T, Waltner-Law M, Scott DK, "et al." |title=A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26098–102 |year= 2002 |pmid= 12118039 |doi= 10.1074/jbc.M204013200
*cite journal | author=Ueda T, Mawji NR, Bruchovsky N, Sadar MD |title=Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38087–94 |year= 2002 |pmid= 12163482 |doi= 10.1074/jbc.M203313200
*cite journal | author=Lanz RB, Razani B, Goldberg AD, O'Malley BW |title=Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16081–6 |year= 2003 |pmid= 12444263 |doi= 10.1073/pnas.192571399
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Emberley E, Huang GJ, Hamedani MK, "et al." |title=Identification of new human coding steroid receptor RNA activator isoforms. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 509–15 |year= 2003 |pmid= 12565891 |doi=
*cite journal | author=Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR |title=Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. |journal=J. Mol. Biol. |volume=331 |issue= 4 |pages= 815–28 |year= 2003 |pmid= 12909012 |doi=
*cite journal | author=Deblois G, Giguère V |title=Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 123–31 |year= 2003 |pmid= 12943696 |doi=
*cite journal | author=Lanz RB, Chua SS, Barron N, "et al." |title=Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7163–76 |year= 2003 |pmid= 14517287 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Fleming FJ, Hill AD, McDermott EW, "et al." |title=Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 1 |pages= 375–83 |year= 2004 |pmid= 14715875 |doi=
*cite journal | author=Chooniedass-Kothari S, Emberley E, Hamedani MK, "et al." |title=The steroid receptor RNA activator is the first functional RNA encoding a protein. |journal=FEBS Lett. |volume=566 |issue= 1-3 |pages= 43–7 |year= 2004 |pmid= 15147866 |doi= 10.1016/j.febslet.2004.03.104
*cite journal | author=Xu B, Koenig RJ |title=An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33051–6 |year= 2004 |pmid= 15180993 |doi= 10.1074/jbc.M404930200
*cite journal | author=Zhao X, Patton JR, Davis SL, "et al." |title=Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator. |journal=Mol. Cell |volume=15 |issue= 4 |pages= 549–58 |year= 2004 |pmid= 15327771 |doi= 10.1016/j.molcel.2004.06.044
*cite journal | author=Coleman KM, Lam V, Jaber BM, "et al." |title=SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 332–8 |year= 2004 |pmid= 15351741 |doi= 10.1016/j.bbrc.2004.08.090
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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