MDC1

MDC1

Mediator of DNA damage checkpoint 1, also known as MDC1, is a human gene.cite web | title = Entrez Gene: MDC1 mediator of DNA damage checkpoint 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9656| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.cite web | title = Entrez Gene: MDC1 mediator of DNA damage checkpoint 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9656| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stucki M, Jackson SP |title=MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 953–7 |year= 2005 |pmid= 15279781 |doi= 10.1016/j.dnarep.2004.03.007
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17–24 |year= 1996 |pmid= 8724849 |doi=
*cite journal | author=Ozaki T, Nagase T, Ichimiya S, "et al." |title=NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain. |journal=DNA Cell Biol. |volume=19 |issue= 8 |pages= 475–85 |year= 2000 |pmid= 10975465 |doi= 10.1089/10445490050128403
*cite journal | author=Shang YL, Bodero AJ, Chen PL |title=NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6323–9 |year= 2003 |pmid= 12475977 |doi= 10.1074/jbc.M210749200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Xu X, Stern DF |title=NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8795–803 |year= 2003 |pmid= 12499369 |doi= 10.1074/jbc.M211392200
*cite journal | author=Peng A, Chen PL |title=NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 8873–6 |year= 2003 |pmid= 12551934 |doi= 10.1074/jbc.C300001200
*cite journal | author=Goldberg M, Stucki M, Falck J, "et al." |title=MDC1 is required for the intra-S-phase DNA damage checkpoint. |journal=Nature |volume=421 |issue= 6926 |pages= 952–6 |year= 2003 |pmid= 12607003 |doi= 10.1038/nature01445
*cite journal | author=Lou Z, Minter-Dykhouse K, Wu X, Chen J |title=MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. |journal=Nature |volume=421 |issue= 6926 |pages= 957–61 |year= 2003 |pmid= 12607004 |doi= 10.1038/nature01447
*cite journal | author=Stewart GS, Wang B, Bignell CR, "et al." |title=MDC1 is a mediator of the mammalian DNA damage checkpoint. |journal=Nature |volume=421 |issue= 6926 |pages= 961–6 |year= 2003 |pmid= 12607005 |doi= 10.1038/nature01446
*cite journal | author=Lou Z, Chini CC, Minter-Dykhouse K, Chen J |title=Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13599–602 |year= 2003 |pmid= 12611903 |doi= 10.1074/jbc.C300060200
*cite journal | author=Xu X, Stern DF |title=NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. |journal=FASEB J. |volume=17 |issue= 13 |pages= 1842–8 |year= 2003 |pmid= 14519663 |doi= 10.1096/fj.03-0310com
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200
*cite journal | author=Mochan TA, Venere M, DiTullio RA, Halazonetis TD |title=53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. |journal=Cancer Res. |volume=63 |issue= 24 |pages= 8586–91 |year= 2004 |pmid= 14695167 |doi=
*cite journal | author=Lukas C, Melander F, Stucki M, "et al." |title=Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. |journal=EMBO J. |volume=23 |issue= 13 |pages= 2674–83 |year= 2005 |pmid= 15201865 |doi= 10.1038/sj.emboj.7600269
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Lou Z, Chen BP, Asaithamby A, "et al." |title=MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46359–62 |year= 2004 |pmid= 15377652 |doi= 10.1074/jbc.C400375200
*cite journal | author=Polci R, Peng A, Chen PL, "et al." |title=NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. |journal=Cancer Res. |volume=64 |issue= 24 |pages= 8800–3 |year= 2005 |pmid= 15604234 |doi= 10.1158/0008-5472.CAN-04-2243

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