HIST2H2AA3

Histone cluster 2, H2aa3, also known as HIST2H2AA3, is a human gene.cite web | title = Entrez Gene: HIST2H2AA3 histone cluster 2, H2aa3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8337| accessdate = ]

PBB_Summary
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summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.cite web | title = Entrez Gene: HIST2H2AA3 histone cluster 2, H2aa3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8337| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
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*cite journal | author=Marashi F, Prokopp K, Stein J, Stein G |title=Evidence for a human histone gene cluster containing H2B and H2A pseudogenes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 7 |pages= 1936–40 |year= 1984 |pmid= 6326092 |doi=
*cite journal | author=Mannironi C, Orr A, Hatch C, "et al." |title=The relative expression of human histone H2A genes is similar in different types of proliferating cells. |journal=DNA Cell Biol. |volume=13 |issue= 2 |pages= 161–70 |year= 1994 |pmid= 8179821 |doi=
*cite journal | author=Kaiser P, Mandl S, Schweiger M, Schneider R |title=Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2. |journal=FEBS Lett. |volume=377 |issue= 2 |pages= 193–6 |year= 1996 |pmid= 8543049 |doi=
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*cite journal | author=Deng L, de la Fuente C, Fu P, "et al." |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593
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*cite journal | author=Deng L, Wang D, de la Fuente C, "et al." |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129
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*cite journal | author=Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G |title=CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. |journal=Mol. Cell |volume=13 |issue= 2 |pages= 291–8 |year= 2004 |pmid= 14759373 |doi=
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*cite journal | author=Aihara H, Nakagawa T, Yasui K, "et al." |title=Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. |journal=Genes Dev. |volume=18 |issue= 8 |pages= 877–88 |year= 2004 |pmid= 15078818 |doi= 10.1101/gad.1184604
*cite journal | author=Wang H, Wang L, Erdjument-Bromage H, "et al." |title=Role of histone H2A ubiquitination in Polycomb silencing. |journal=Nature |volume=431 |issue= 7010 |pages= 873–8 |year= 2004 |pmid= 15386022 |doi= 10.1038/nature02985
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
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