PRDM2

PR domain containing 2, with ZNF domain, also known as PRDM2, is a human gene.cite web | title = Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7799| accessdate = ]

PBB_Summary
section_title =
summary_text = This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7799| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Buyse IM, Shao G, Huang S |title=The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 10 |pages= 4467–71 |year= 1995 |pmid= 7538672 |doi=
*cite journal | author=Shapiro VS, Lee P, Winoto A |title=Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3. |journal=Gene |volume=163 |issue= 2 |pages= 329–30 |year= 1995 |pmid= 7590293 |doi=
*cite journal | author=Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S |title=cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene. |journal=Eur. J. Biochem. |volume=235 |issue= 3 |pages= 471–9 |year= 1996 |pmid= 8654390 |doi=
*cite journal | author=Buyse IM, Takahashi EI, Huang S |title=Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36. |journal=Genomics |volume=34 |issue= 1 |pages= 119–21 |year= 1996 |pmid= 8661032 |doi= 10.1006/geno.1996.0249
*cite journal | author=Liu L, Shao G, Steele-Perkins G, Huang S |title=The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2984–91 |year= 1997 |pmid= 9006946 |doi=
*cite journal | author=Xie M, Shao G, Buyse IM, Huang S |title=Transcriptional repression mediated by the PR domain zinc finger gene RIZ. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26360–6 |year= 1997 |pmid= 9334209 |doi=
*cite journal | author=He L, Yu JX, Liu L, "et al." |title=RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis. |journal=Cancer Res. |volume=58 |issue= 19 |pages= 4238–44 |year= 1998 |pmid= 9766644 |doi=
*cite journal | author=Abbondanza C, Medici N, Nigro V, "et al." |title=The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3130–5 |year= 2000 |pmid= 10706618 |doi= 10.1073/pnas.050015697
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Du Y, Carling T, Fang W, "et al." |title=Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8094–9 |year= 2001 |pmid= 11719434 |doi=
*cite journal | author=Sasaki O, Meguro K, Tohmiya Y, "et al." |title=Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia. |journal=Tohoku J. Exp. Med. |volume=196 |issue= 3 |pages= 193–201 |year= 2003 |pmid= 12002276 |doi=
*cite journal | author=Poetsch M, Dittberner T, Woenckhaus C |title=Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36. |journal=Oncogene |volume=21 |issue= 19 |pages= 3038–42 |year= 2002 |pmid= 12082534 |doi= 10.1038/sj.onc.1205457
*cite journal | author=Sasaki O, Meguro K, Tohmiya Y, "et al." |title=Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia. |journal=Br. J. Haematol. |volume=119 |issue= 4 |pages= 940–8 |year= 2003 |pmid= 12472571 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tokumaru Y, Nomoto S, Jerónimo C, "et al." |title=Biallelic inactivation of the RIZ1 gene in human gastric cancer. |journal=Oncogene |volume=22 |issue= 44 |pages= 6954–8 |year= 2003 |pmid= 14534544 |doi= 10.1038/sj.onc.1206403
*cite journal | author=Kim KC, Geng L, Huang S |title=Inactivation of a histone methyltransferase by mutations in human cancers. |journal=Cancer Res. |volume=63 |issue= 22 |pages= 7619–23 |year= 2004 |pmid= 14633678 |doi=
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Pan KF, Lu YY, Liu WG, "et al." |title=Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability. |journal=World J. Gastroenterol. |volume=10 |issue= 18 |pages= 2719–22 |year= 2004 |pmid= 15309726 |doi=
*cite journal | author=Rossi M, Abbondanza C, D'Arcangelo A, "et al." |title=The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation. |journal=Cancer Lett. |volume=215 |issue= 2 |pages= 229–37 |year= 2004 |pmid= 15488642 |doi= 10.1016/j.canlet.2004.05.014
*cite journal | author=Grundberg E, Carling T, Brändström H, "et al." |title=A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 12 |pages= 6173–8 |year= 2005 |pmid= 15579774 |doi= 10.1210/jc.2004-0403

External links

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