TSN (gene)

Translin, also known as TSN, is a human gene.cite web | title = Entrez Gene: TSN translin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7247| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.cite web | title = Entrez Gene: TSN translin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7247| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Aoki K, Suzuki K, Sugano T, "et al." |title=A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. |journal=Nat. Genet. |volume=10 |issue= 2 |pages= 167–74 |year= 1995 |pmid= 7663511 |doi= 10.1038/ng0695-167
*cite journal | author=Kasai M, Aoki K, Matsuo Y, "et al." |title=Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11). |journal=Int. Immunol. |volume=6 |issue= 7 |pages= 1017–25 |year= 1994 |pmid= 7947454 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Aoki K, Nakahara K, Ikegawa C, "et al." |title=Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family. |journal=Oncogene |volume=9 |issue= 4 |pages= 1109–15 |year= 1994 |pmid= 8134113 |doi=
*cite journal | author=Aoki K, Ishida R, Kasai M |title=Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 109–12 |year= 1997 |pmid= 9013868 |doi=
*cite journal | author=Kasai M, Matsuzaki T, Katayanagi K, "et al." |title=The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11402–7 |year= 1997 |pmid= 9111049 |doi=
*cite journal | author=Aoki K, Inazawa J, Takahashi T, "et al." |title=Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein. |journal=Genomics |volume=43 |issue= 2 |pages= 237–41 |year= 1997 |pmid= 9244443 |doi= 10.1006/geno.1997.4796
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hasegawa T, Isobe K |title=Evidence for the interaction between Translin and GADD34 in mammalian cells. |journal=Biochim. Biophys. Acta |volume=1428 |issue= 2-3 |pages= 161–8 |year= 1999 |pmid= 10434033 |doi=
*cite journal | author=Badge RM, Yardley J, Jeffreys AJ, Armour JA |title=Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination. |journal=Hum. Mol. Genet. |volume=9 |issue= 8 |pages= 1239–44 |year= 2000 |pmid= 10767349 |doi=
*cite journal | author=Hosaka T, Kanoe H, Nakayama T, "et al." |title=Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6). |journal=Oncogene |volume=19 |issue= 50 |pages= 5821–5 |year= 2001 |pmid= 11126370 |doi= 10.1038/sj.onc.1203943
*cite journal | author=Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB |title=Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13256–63 |year= 2001 |pmid= 11278549 |doi= 10.1074/jbc.M009707200
*cite journal | author=Lee SP, Fuior E, Lewis MS, Han MK |title=Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide. |journal=Biochemistry |volume=40 |issue= 46 |pages= 14081–8 |year= 2001 |pmid= 11705401 |doi=
*cite journal | author=Erdemir T, Bilican B, Oncel D, "et al." |title=DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). |journal=J. Cell. Sci. |volume=115 |issue= Pt 1 |pages= 207–16 |year= 2002 |pmid= 11801738 |doi=
*cite journal | author=Han MK, Lin P, Paek D, "et al." |title=Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer. |journal=Biochemistry |volume=41 |issue= 10 |pages= 3468–76 |year= 2002 |pmid= 11876655 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sengupta K, Rao BJ |title=Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions. |journal=Biochemistry |volume=41 |issue= 51 |pages= 15315–26 |year= 2003 |pmid= 12484770 |doi=
*cite journal | author=Li K, Wang L, Cheng J, "et al." |title=Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus. |journal=World J. Gastroenterol. |volume=9 |issue= 2 |pages= 300–3 |year= 2003 |pmid= 12532453 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yang S, Cho YS, Chennathukuzhi VM, "et al." |title=Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12605–14 |year= 2004 |pmid= 14711818 |doi= 10.1074/jbc.M313133200

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