Ferritin light chain

Ferritin light chain

Ferritin, light polypeptide, also known as FTL, is a human gene.cite web | title = Entrez Gene: FTL ferritin, light polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2512| accessdate = ]

section_title =
summary_text = This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.cite web | title = Entrez Gene: FTL ferritin, light polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2512| accessdate = ]

ee also

* Ferritin


Further reading

citations =
*cite journal | author=Munro HN, Aziz N, Leibold EA, "et al." |title=The ferritin genes: structure, expression, and regulation. |journal=Ann. N. Y. Acad. Sci. |volume=526 |issue= |pages= 113–23 |year= 1988 |pmid= 3291676 |doi=
*cite journal | author=Cazzola M, Skoda RC |title=Translational pathophysiology: a novel molecular mechanism of human disease. |journal=Blood |volume=95 |issue= 11 |pages= 3280–8 |year= 2000 |pmid= 10828006 |doi=
*cite journal | author=Arosio P, Adelman TG, Drysdale JW |title=On ferritin heterogeneity. Further evidence for heteropolymers. |journal=J. Biol. Chem. |volume=253 |issue= 12 |pages= 4451–8 |year= 1978 |pmid= 659425 |doi=
*cite journal | author=Gatti RA, Shaked R, Mohandas TK, Salser W |title=Human ferritin genes: chromosomal assignments and polymorphisms. |journal=Am. J. Hum. Genet. |volume=41 |issue= 4 |pages= 654–67 |year= 1987 |pmid= 2821803 |doi=
*cite journal | author=Lebo RV, Kan YW, Cheung MC, "et al." |title=Human ferritin light chain gene sequences mapped to several sorted chromosomes. |journal=Hum. Genet. |volume=71 |issue= 4 |pages= 325–8 |year= 1986 |pmid= 3000916 |doi=
*cite journal | author=Chou CC, Gatti RA, Fuller ML, "et al." |title=Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro. |journal=Mol. Cell. Biol. |volume=6 |issue= 2 |pages= 566–73 |year= 1987 |pmid= 3023856 |doi=
*cite journal | author=Santoro C, Marone M, Ferrone M, "et al." |title=Cloning of the gene coding for human L apoferritin. |journal=Nucleic Acids Res. |volume=14 |issue= 7 |pages= 2863–76 |year= 1986 |pmid= 3754330 |doi=
*cite journal | author=Boyd D, Vecoli C, Belcher DM, "et al." |title=Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones. |journal=J. Biol. Chem. |volume=260 |issue= 21 |pages= 11755–61 |year= 1985 |pmid= 3840162 |doi=
*cite journal | author=Worwood M, Brook JD, Cragg SJ, "et al." |title=Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter. |journal=Hum. Genet. |volume=69 |issue= 4 |pages= 371–4 |year= 1985 |pmid= 3857215 |doi=
*cite journal | author=Dörner MH, Salfeld J, Will H, "et al." |title=Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3139–43 |year= 1985 |pmid= 3858810 |doi=
*cite journal | author=Caskey JH, Jones C, Miller YE, Seligman PA |title=Human ferritin gene is assigned to chromosome 19. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=80 |issue= 2 |pages= 482–6 |year= 1983 |pmid= 6572903 |doi=
*cite journal | author=Addison JM, Fitton JE, Lewis WG, "et al." |title=The amino acid sequence of human liver apoferritin. |journal=FEBS Lett. |volume=164 |issue= 1 |pages= 139–44 |year= 1984 |pmid= 6653779 |doi=
*cite journal | author=Girelli D, Corrocher R, Bisceglia L, "et al." |title=Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation") |journal=Blood |volume=86 |issue= 11 |pages= 4050–3 |year= 1996 |pmid= 7492760 |doi=
*cite journal | author=Beaumont C, Leneuve P, Devaux I, "et al." |title=Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract. |journal=Nat. Genet. |volume=11 |issue= 4 |pages= 444–6 |year= 1996 |pmid= 7493028 |doi= 10.1038/ng1295-444
*cite journal | author=D'Agostino P, Faniello MC, Quaresima B, "et al." |title=Negative and positive elements in the promoter region of the human apoferritin L gene. |journal=Biochem. Biophys. Res. Commun. |volume=215 |issue= 1 |pages= 329–37 |year= 1995 |pmid= 7575610 |doi=
*cite journal | author=Rogers JT, Andriotakis JL, Lacroix L, "et al." |title=Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5' leader sequences distinct from the iron responsive element. |journal=Nucleic Acids Res. |volume=22 |issue= 13 |pages= 2678–86 |year= 1994 |pmid= 8041631 |doi=
*cite journal | author=Spanner M, Weber K, Lanske B, "et al." |title=The iron-binding protein ferritin is expressed in cells of the osteoblastic lineage in vitro and in vivo. |journal=Bone |volume=17 |issue= 2 |pages= 161–5 |year= 1996 |pmid= 8554925 |doi=
*cite journal | author=Rogers JT |title=Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. |journal=Blood |volume=87 |issue= 6 |pages= 2525–37 |year= 1996 |pmid= 8630420 |doi=
*cite journal | author=Pang JH, Jiang MJ, Chen YL, "et al." |title=Increased ferritin gene expression in atherosclerotic lesions. |journal=J. Clin. Invest. |volume=97 |issue= 10 |pages= 2204–12 |year= 1996 |pmid= 8636399 |doi=

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