PPP2R1B

Protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform, also known as PPP2R1B, is a human gene.cite web | title = Entrez Gene: PPP2R1B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5519| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: PPP2R1B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5519| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=
*cite journal | author=Kamibayashi C, Lickteig RL, Estes R, "et al." |title=Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits. |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21864–72 |year= 1992 |pmid= 1328247 |doi=
*cite journal | author=Hemmings BA, Adams-Pearson C, Maurer F, "et al." |title=alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. |journal=Biochemistry |volume=29 |issue= 13 |pages= 3166–73 |year= 1990 |pmid= 2159327 |doi=
*cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, "et al." |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=
*cite journal | author=Adler HT, Nallaseth FS, Walter G, Tkachuk DC |title=HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28407–14 |year= 1997 |pmid= 9353299 |doi=
*cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873
*cite journal | author=Wang SS, Esplin ED, Li JL, "et al." |title=Alterations of the PPP2R1B gene in human lung and colon cancer. |journal=Science |volume=282 |issue= 5387 |pages= 284–7 |year= 1998 |pmid= 9765152 |doi=
*cite journal | author=Baysal BE, Farr JE, Goss JR, "et al." |title=Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. |journal=Gene |volume=217 |issue= 1-2 |pages= 107–16 |year= 1998 |pmid= 9795170 |doi=
*cite journal | author=Takahashi M, Shibata H, Shimakawa M, "et al." |title=Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17267–74 |year= 1999 |pmid= 10358086 |doi=
*cite journal | author=Campbell IG, Manolitsas T |title=Absence of PPP2R1B gene alterations in primary ovarian cancers. |journal=Oncogene |volume=18 |issue= 46 |pages= 6367–9 |year= 2000 |pmid= 10597236 |doi= 10.1038/sj.onc.1203070
*cite journal | author=Takagi Y, Futamura M, Yamaguchi K, "et al." |title=Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. |journal=Gut |volume=47 |issue= 2 |pages= 268–71 |year= 2000 |pmid= 10896920 |doi=
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956
*cite journal | author=Baysal BE, Willett-Brozick JE, Taschner PE, "et al." |title=A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. |journal=Eur. J. Hum. Genet. |volume=9 |issue= 2 |pages= 121–9 |year= 2001 |pmid= 11313745 |doi= 10.1038/sj.ejhg.5200585
*cite journal | author=Ruediger R, Pham HT, Walter G |title=Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. |journal=Oncogene |volume=20 |issue= 15 |pages= 1892–9 |year= 2001 |pmid= 11313937 |doi= 10.1038/sj.onc.1204279
*cite journal | author=Yokoyama N, Reich NC, Miller WT |title=Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway. |journal=J. Interferon Cytokine Res. |volume=21 |issue= 6 |pages= 369–78 |year= 2001 |pmid= 11440634 |doi= 10.1089/107999001750277844
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007
*cite journal | author=Yang J, Fan GH, Wadzinski BE, "et al." |title=Protein phosphatase 2A interacts with and directly dephosphorylates RelA. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 47828–33 |year= 2002 |pmid= 11591705 |doi= 10.1074/jbc.M106103200
*cite journal | author=Strack S, Ruediger R, Walter G, "et al." |title=Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20750–5 |year= 2002 |pmid= 11929880 |doi= 10.1074/jbc.M202992200
*cite journal | author=Hemmer S, Wasenius VM, Haglund C, "et al." |title=Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. |journal=Cancer Genet. Cytogenet. |volume=134 |issue= 1 |pages= 13–7 |year= 2002 |pmid= 11996789 |doi=

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