UBQLN1

Ubiquilin 1, also known as UBQLN1, is a human gene.cite web | title = Entrez Gene: UBQLN1 ubiquilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979| accessdate = ]

PBB_Summary
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summary_text = This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: UBQLN1 ubiquilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ozaki T, Kondo K, Nakamura Y, "et al." |title=Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5). |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 245–50 |year= 1997 |pmid= 9268694 |doi= 10.1006/bbrc.1997.7122
*cite journal | author=Ozaki T, Hishiki T, Toyama Y, "et al." |title=Identification of a new cellular protein that can interact specifically with DAN. |journal=DNA Cell Biol. |volume=16 |issue= 8 |pages= 985–91 |year= 1997 |pmid= 9303440 |doi=
*cite journal | author=Ozaki T, Hanaoka E, Naka M, "et al." |title=Cloning and characterization of rat BAT3 cDNA. |journal=DNA Cell Biol. |volume=18 |issue= 6 |pages= 503–12 |year= 1999 |pmid= 10390159 |doi= 10.1089/104454999315222
*cite journal | author=Wu AL, Wang J, Zheleznyak A, Brown EJ |title=Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. |journal=Mol. Cell |volume=4 |issue= 4 |pages= 619–25 |year= 1999 |pmid= 10549293 |doi=
*cite journal | author=Hanaoka E, Ozaki T, Ohira M, "et al." |title=Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3. |journal=J. Hum. Genet. |volume=45 |issue= 3 |pages= 188–91 |year= 2000 |pmid= 10807547 |doi=
*cite journal | author=Kleijnen MF, Shih AH, Zhou P, "et al." |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409–19 |year= 2000 |pmid= 10983987 |doi=
*cite journal | author=Mah AL, Perry G, Smith MA, Monteiro MJ |title=Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 847–62 |year= 2000 |pmid= 11076969 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Bedford FK, Kittler JT, Muller E, "et al." |title=GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. |journal=Nat. Neurosci. |volume=4 |issue= 9 |pages= 908–16 |year= 2001 |pmid= 11528422 |doi= 10.1038/nn0901-908
*cite journal | author=Wu S, Mikhailov A, Kallo-Hosein H, "et al." |title=Characterization of ubiquilin 1, an mTOR-interacting protein. |journal=Biochim. Biophys. Acta |volume=1542 |issue= 1-3 |pages= 41–56 |year= 2002 |pmid= 11853878 |doi=
*cite journal | author=Ko HS, Uehara T, Nomura Y |title=Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35386–92 |year= 2002 |pmid= 12095988 |doi= 10.1074/jbc.M203412200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gao L, Tu H, Shi ST, "et al." |title=Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase. |journal=J. Virol. |volume=77 |issue= 7 |pages= 4149–59 |year= 2003 |pmid= 12634373 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Massey LK, Mah AL, Ford DL, "et al." |title=Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins. |journal=J. Alzheimers Dis. |volume=6 |issue= 1 |pages= 79–92 |year= 2004 |pmid= 15004330 |doi=
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Persson P, Stockhausen MT, Påhlman S, Axelson H |title=Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells. |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1213–21 |year= 2005 |pmid= 15492808 |doi=
*cite journal | author=Bertram L, Hiltunen M, Parkinson M, "et al." |title=Family-based association between Alzheimer's disease and variants in UBQLN1. |journal=N. Engl. J. Med. |volume=352 |issue= 9 |pages= 884–94 |year= 2005 |pmid= 15745979 |doi= 10.1056/NEJMoa042765

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